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|Title: ||TPH1 and 5-HTTLPR genes specifically interact in opiate dependence but not in alcohol dependence|
|Authors: ||王姿云;Wang, Tzu-Yun;李聖玉;Lee, Sheng-Yu;鍾宜倫;Chung, Yi-Lun;陳秀蘭;Chen, Shiou-Lan;李佳玲;Li, Chia-Ling;張芸瑄;Chang, Yun-Hsuan;王亮人;Wang, Liang-Jen;陳柏熹;Chen, Po See;黃三原;San-Yuan Huang;曾念生;Nain-Shen Tzeng;謝采芯;Hsieh, Tsai-Hsin;李怡慧;Lee, I Hui;陳高欽;Chen, Kao-Chin;楊延光;Yang, Yen Kuang|
|Issue Date: ||2016-08-08 14:27:11 (UTC+8)|
|Abstract: ||Background: Different drug dependencies may have unique genetic vulnerabilities. Changes in serotonin availability and function have been linked to addiction. We investigated whether 2 serotonergic polymorphisms, TPH1 A218C (rs1800532) and 5-HTT-linked promoter region (5-HTTLPR) (rs25531), are differently associated with alcohol or opiate dependence. Methods: Alcohol-dependent patients (n = 292), opiate-dependent patients (n = 309), and healthy controls (n = 301) were recruited from the Han Chinese population in Taiwan. Genotypes of TPH1 A218C and 5-HTTLPR polymorphisms were analyzed using a polymerase chain reaction with restriction fragment length polymorphism. Results: The genotype frequencies of the TPH1 A218C polymorphisms were not significantly different in the 3 groups. The genotype frequencies of the 5-HTTLPR S+ (S/S, S/LG, LG/LG) polymorphisms were significantly higher in opiate-dependent patients (χ2 = 8.77, p = 0.01), but not after controlling for the covariates of age, gender, and interaction effect in logistic regression analysis. Moreover, there was a significant interaction between the TPH1 A218C A/C and 5-HTTLPR S+ gene polymorphisms in opiate-dependent (OR 2.72, p = 0.01), but not in alcohol-dependent patients. Conclusions: Our data suggested that there may be a differential genetic vulnerability in serotonergic genes for alcohol and opiate addiction. However, replications of our findings are still needed.|
|Relation: ||EUROPEAN ADDICTION RESEARCH|
|Appears in Collections:||[心理學系] 期刊論文|
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