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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/100281


    Title: Paeoniflorin inhibits excitatory amino acid agonist and highdose Morphine induced nociceptive behavior in mice via modulation of N-methyl-D-aspartate receptors
    Authors: 陳玉芳;Chen, Yuh-Fung;*;李明明;Lee, Min-Min;Fa, Hsun-Lang;Fan, Hsun-Lang;Ya, Jhao-Guei;Yang, Jhao-Guei;Che, Yu-Chien;Chen, Yu-Chien;蔡輝彥;Tsai, Huei-Yann
    Contributors: 保健營養生技學系
    Date: 2016-07
    Issue Date: 2016-08-08 14:46:03 (UTC+8)
    Abstract: Background
    Pain, the most common reasons for physician consultation, is a major symptom in many medical conditions that can significantly interfere with a person’s life quality and general functioning. Almost all painkillers have its untoward effects. Therefore, seeking for a safe medication for pain relieve is notable nowadays. Paeonia lactiflora is a well-known traditional Chinese medicine. Paeoniflorin is an active component found in Paeonia lactiflora, which has been reported to inhibit formalin-induced nociceptive behavior in mice. Aims of this present study were to investigate effects of paeoniflorin on excitatory amino acid agonist- or high-dose morphine-induced nociceptive behaviors in mice.

    Results
    Paeoniflorin (100, 200, 500 nmol, i.c.v.) alone and combined with glutamatergic antagonists (MK-801 14.8 pmol, or NBQX 5 nmol, i.t.) inhibited nociception. Those agents also inhibited the clonic seizure-like excitation induced by high-dose morphine (250 nmol, i.t) in mice. Antisense oligodeoxynucleotides of NMDA receptor subunits NR1, NR2A, NR2B significantly enhanced the inhibition of paeoniflorin on excitatory amino acid-and high-dose morphine-induced nociception. Docking energy data revealed that paeoniflorin had stronger binding activity in NR2A and NR2B than NR2C of NMDA receptors.

    Conclusions
    Results of this study indicate that paeoniflorin-induced inhibition of excitatory amino acid agonist- and high-dose morphine-induced nociceptive behaviors might be due to modulation of NMDA receptors, specifically the NR2B subunit.
    Relation: BMC Complementary and Alternative Medicine
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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