ASIA unversity:Item 310904400/101540
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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/101540


    Title: The Differential Levels of Inflammatory Cytokines and BDNF among Bipolar Spectrum Disorders
    Authors: 王姿云;Wang, Tzu-Yun;李聖玉;Lee, Sheng-Yu;陳秀蘭;Chen, Shiou-Lan;鍾宜倫;Chung, Yi-Lun;Li, Chia-Ling;Li, Chia-Ling;張芸瑄;Chang, Yun-Hsuan;王亮人;Wang, Liang-Jen;陳柏熹;Chen, Po See;陳士恆;Chen, Shih-Heng;曾念生;Tzeng, Nian-Sheng;謝采芯;Hsieh, Tsai-Hsin;Chiu, Yen-Chu;Chiu, Yen-Chu;李怡慧;Lee, I Hui
    Contributors: 心理學系
    Objective: Emerging evidence suggests that inflammation and neurodegeneration underlies bipolar disorder. To investigate biological markers of cytokines and brain-derived neurotrophic factor between bipolar I, bipolar II, and other specified bipolar disorder with short duration hypomania may support the association with inflammatory dysregulation and bipolar disorder and, more specifically, provide evidence for other specified bipolar disorder with short duration hypomania patients were similar to bipolar II disorder patients from a biological marker perspective. Methods: We enrolled patients with bipolar I disorder (n=234), bipolar II disorder (n=260), other specified bipolar disorder with short duration hypomania (n=243), and healthy controls (n=140). Their clinical symptoms were rated using the Hamilton Depression Rating Scale and Young Mania Rating Scale. Inflammatory cytokine (tumor necrosis factor-α, C-reactive protein, transforming growth factor-β1, and interleukin-8) and brain-derived neurotrophic factor levels were measured in each group. Multivariate analysis of covariance and linear regression controlled for possible confounders were used to compare cytokine and brain-derived neurotrophic factor levels among the groups. Results: Multivariate analysis of covariance adjusted for age and sex and a main effect of diagnosis was significant (P<.001). Three of the 5 measured biomarkers (tumor necrosis factor-α, transforming growth factor-β1, and interleukin-8) were significantly (P=.006, .01, and <.001) higher in all bipolar disorder patients than in controls. Moreover, covarying for multiple associated confounders showed that bipolar I disorder patients had significantly higher IL-8 levels than did bipolar II disorder and other specified bipolar disorder with short duration hypomania patients in multivariate analysis of covariance (P=.03) and linear regression (P=.02) analyses. Biomarkers differences between bipolar II disorder and other specified bipolar disorder with short duration hypomania patients were nonsignificant.
    Date: 2016-08
    Issue Date: 2016-11-08 10:07:06 (UTC+8)
    Relation: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
    Appears in Collections:[Department of Psychology] Journal Article

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