ASIA unversity:Item 310904400/101793
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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/101793


    Title: Risk of asthma in patients with primary Sj?gren’s syndrome: a retrospective cohort
    Authors: 沈德群;Shen, Te-Chun;Che, Hsuan-Ju;Chen, Hsuan-Ju;Chang-Ching;Wei, Chang-Ching;Ch, Chia-Hung;Chen, Chia-Hung;Tu, Chih-Yen;Tu, Chih-Yen;Hsia, Te-Chun;Hsia, Te-Chun;Chuen-Ming, S;Shih, Chuen-Ming;Hsu, Wu-Huei;Hsu, Wu-Huei;Fung-Chang, S;Sung, Fung-Chang;包大?;Bau*, Da-Tian
    Contributors: 生物資訊與醫學工程學系
    Date: 2016-11
    Issue Date: 2016-12-05 14:15:53 (UTC+8)
    Abstract: Background

    Sjögren’s syndrome (SS) has been associated with bronchial hyperresponsiveness and asthma; however, no population-based cohort study has been performed. We evaluated the risk of asthma in patients with primary SS in a nationwide population.

    Methods

    We conducted a retrospective cohort study using data from the National Health Insurance Research Database in Taiwan. The primary SS group included 4725 adult patients diagnosed between 2000 and 2006. Each patient was frequency-matched with four people without SS by sex, age and year of diagnosis. The occurrence and hazard ratio (HR) of asthma was monitored by the end of 2011.

    Results

    The overall incidence density of asthma was 1.62-fold higher in the primary SS group than in the non-SS group (9.86 vs. 6.10 per 1000 person-years), with a multivariable Cox proportional hazards model measured adjusted HR of 1.38 [95% confidence interval (CI) = 1.21–1.58]. Stratified analyses by sex, age group, and presence of comorbidity revealed that asthma incidences were all higher in the primary SS group than in the non-SS group, and the relative HRs of asthma associated with primary SS were significant in all subgroups.

    Conclusion

    Patients with primary SS are associated with an increased risk of developing asthma. We should pay more attention to this group of individuals and provide them with appropriate support.
    Relation: BMC Pulmonary Medicine
    Appears in Collections:[Department of Biomedical informatics  ] Journal Article

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