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|Title: ||Evaluation of xanthine oxidase inhibitory potential and in vivo hypouricemic activity of Dimocarpus Longan Lour. extracts|
|Authors: ||She, Shi-Yuan;Sheu, Shi-Yuan;Yuan-Tsung, F;Fu, Yuan-Tsung;Huan, Wen-Dar;Huang, Wen-Dar;Che, Yung-Ann;Chen, Yung-Ann;Lei, Yi-Chih;Lei, Yi-Chih;姚俊旭;Yao*, Chun-Hsu;Hsu, Feng-Lin;Hsu, Feng-Lin;Kuo, Tzong-Fu;Kuo, Tzong-Fu|
|Issue Date: ||2016-12-05 14:17:45 (UTC+8)|
Longan is a fruit tree known to contain many phenolic components, which are capable of protecting people from oxidative damage through an anti-inflammatory mechanism. It may be also worthwhile to study the effect on lowering uric acid activity.
Materials and Methods:
This study investigates the lowering of uric acid using longan extracts, including flowers, pericarps, seeds, leaves, and twigs, on potassium-oxonate-induced hyperuricemia mice and its inhibitory actions against xanthine oxidase (XO) activities.
The findings revealed that ethyl acetate fraction of longan extracts exhibited strong XO-inhibitory activity, and the flower extracts (IC50 = 115.8 μg/mL) revealed more potent XO-inhibitory activity to those of pericarps (118.9 μg/mL), twigs (125.3 μg/mL), seeds (262.5 μg/mL), and leaves (331.1 μg/mL) in vitro. In addition, different dosages of longan extract (50–100 mg/kg) were administered to hyperuricemic mice. The lowering effect of longan extracts on uric acid at 75 mg/kg markedly reduced plasma uric acid levels in decreasing order: Flowers (80%) > seeds (72%) > pericarps (64%) > twigs (59%) > leaves (41%), compared with allopurinol (89%). Finally, 10 isolated phytochemicals from longan flowers were then examined in vitro. The results indicated that proanthocyanidin A2 and acetonylgeraniin A significantly inhibited XO activity in vitro. This is the first report providing new insights into the urate-reducing effect of phenolic dimer and hydrolyzable tannin, which can be developed to potential hypouricemic agents.
|Relation: ||Pharmacognosy Magazine|
|Appears in Collections:||[生物資訊與醫學工程學系 ] 期刊論文|
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