English  |  正體中文  |  简体中文  |  Items with full text/Total items : 92472/107769 (86%)
Visitors : 19067737      Online Users : 522
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version
    ASIA unversity > 醫學暨健康學院 > 心理學系 > 期刊論文 >  Item 310904400/102034

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/102034

    Title: Effects of Taxol on Regeneration in a Rat Sciatic Nerve Transection Model
    Authors: 許世典;Hsu, Shih-Tien;姚俊旭;Yao, Chun-Hsu;徐媛曼;林佳弘;Lin, Jia-Horng;陳永祥;Chen, Yung-Hsian;陳悅生;Chen, Yueh-Sheng;*
    Contributors: 心理學系
    Date: 2017-02
    Issue Date: 2017-03-01 13:40:23 (UTC+8)
    Abstract: Recent studies describe taxol as a candidate treatment for promoting central nerve regeneration. However, taxol has serious side effects including peripheral neurotoxicity, and little information is known about the effect of taxol on peripheral nerve regeneration. We investigated the effects of taxol on regeneration in a rat sciatic nerve transection model. Rats were divided into four groups (n = 10): normal saline (i.p.) as the control, Cremophor EL vehicle, and 2 or 6 mg/kg of taxol in the Cremophor EL solution (four times in day-2, 4, 6, and 8), respectively. We evaluated neuronal electrophysiology, animal behaviour, neuronal connectivity, macrophage infiltration, location and expression levels of calcitonin gene-related peptide (CGRP), and expression levels of both nerve growth factors and immunoregulatory factors. In the high-dose taxol group (6 mg/kg), neuronal electrophysiological function was significantly impaired. Licking latencies were significantly changed while motor coordination was unaffected. Neuronal connectivity, macrophage density, and expression levels of CGRP was dramatically reduced. Expression levels of nerve growth factors and immunoregulatory factors was also reduced, while it was increased in the low-dose taxol group (2 mg/kg). These results indicate that taxol can modulate local inflammatory conditions, impair nerve regeneration, and impede recovery of a severe peripheral nerve injury.
    Relation: Scientific Reports
    Appears in Collections:[心理學系] 期刊論文

    Files in This Item:

    File SizeFormat

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback