English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90453/105672 (86%)
Visitors : 13306306      Online Users : 709
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/102082

    Title: S-endo-2-Norbornyl-N-n-butylcarbamate as a Potential Pseudomonas Lipase Inhibitor to Probe the Enantioselectivity of the Enzyme by Kinetic and Molecular Docking Evaluation
    Authors: 沈育芳;Shen, Yu-Fang;Che, Gan-Hong;Chen, Gan-Hong;Li, Shu-Hsien;Lin, Shu-Hsien;Lin, Gialih;Lin, Gialih;*
    Contributors: 生物資訊與醫學工程學系
    Date: 2016-06
    Issue Date: 2017-03-01 13:49:08 (UTC+8)
    Abstract: Obesity is a complex health issue and it can cause many health and social problems. Previous studies reported that lipase is a main target for obesity treatment. We synthesized R-exo-2-norbornyl-N-n-butylcarbamate and S-exo-2-norbornyl-N-n-butylcarbamate as potential pseudomonas lipase inhibitors to probe the enantioselectivity of the enzyme and demonstrated that R-exo-2-norbornyl-N-n-butylcarbamate had better enzyme enantioselectivity, ki and the docking model with Pseudomonas species lipase in our previous studies. In this article, we reported the property of the Pseudomonas species lipase inhibitors, R-and S-endo-2-norbornyl-N-n-butylcarbamate and compared the docking models of these two compounds with R- and S-exo-2-norbornyl-N-n-butylcarbamates by AutoDock. We found that S-endo-2-norbornyl-N-n-butylcarbamate has the best enantioselectivity, ki and docking model and this study could provide useful information about enzyme enantioselectivity for the development of Pseudomonas species lipase inhibitors for obesity treatment.
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

    Files in This Item:

    File SizeFormat

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback