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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/102083


    Title: Hinokitiol-loaded mesoporous calcium silicate nanoparticle induce apoptotic cell death through regulation of the function of MDR1 in lung adenocarcinoma cells
    Authors: 沈育芳;Shen, Yu-Fang;Ho, Chia-Che;Shi, Ming-You;Shie, Ming-You;Wang, Kan;Wang, Kan;Fa, Hsin-Yuan;Fang, Hsin-Yuan;*
    Contributors: 生物資訊與醫學工程學系
    Date: 2016-04
    Issue Date: 2017-03-01 13:49:15 (UTC+8)
    Abstract: Hinokitiol is a tropolone-related compound found in heartwood cupressaceous plants. Hinokitiol slows the growth of a variety of cancers through inhibition of cell proliferation. The low water solubility of hinokitiol leads to less bioavailability. This has been highlighted as a major limiting factor. In this study, mesoporous calcium silicate (MCS) nanoparticles, both pure and hinokitiol-loaded, were synthesized and their effects on A549 cells were analyzed. The results indicate that Hino-MCS nanoparticles induce apoptosis in higher concentration loads (>12.5 μg/mL) for A549 cells. Hino-MCS nanoparticles suppress gene and protein expression levels of multiple drug resistance protein 1 (MDR1). In addition, both the activity and the expression levels of caspase-3/-9 were measured in Hino-MCS nanoparticle-treated A549 cells. The Hino-MCS nanoparticles-triggered apoptosis was blocked by inhibitors of pan-caspase, caspase-3/-9, and antioxidant agents (N-acetylcysteine; NAC). The Hino-MCS nanoparticles enhance reactive oxygen species production and the protein expression levels of caspase-3/-9. Our data suggest that Hino-MCS nanoparticles trigger an intrinsic apoptotic pathway through regulating the function of MDR1 and the production of reactive oxygen species in A549 cells. Therefore, we believe that Hino-MCS nanoparticles may be efficacious in the treatment of drug-resistant human lung cancer in the future.
    Relation: Materials
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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