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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/102094

    Title: Mesoporous calcium silicate nanoparticles with drug delivery and odontogenesis properties
    Authors: 黃靖媛;Huang, Ching-Yuang;Tsui-Hsien, Hsien H;Huang, Tsui-Hsien;Kao, Chia-Tze;Kao, Chia-Tze;Wu, Yuan-Haw;Wu, Yuan-Haw;Che, Wan-Chen;Chen, Wan-Chen;謝明佑;Shie, Ming-You;*
    Contributors: 生物資訊與醫學工程學系
    Date: 2017-01
    Issue Date: 2017-03-01 13:52:03 (UTC+8)
    Abstract: Introduction: Calcium silicate (CS) –based materials
    play an important role in the development of endodontic
    materials that induce bone/cementum tissue regeneration
    and inhibit bacterial viability. The aim of this study
    was to prepare novel mesoporous CS (MesoCS) nanoparticles
    that have osteogenic, drug delivery, and antibacterial
    characteristics for endodontic materials and
    also have an excellent ability to develop apatite mineralization.
    Methods: The MesoCS nanoparticles were
    prepared using sol-gel methods. In addition, the mesoporous
    structure, specific surface area, pore volume,
    and morphology of the MesoCS nanoparticles were
    analyzed. The apatite mineralization ability, in vitro
    odontogenic differentiation, drug delivery, and antibacterial
    properties of the MesoCS nanoparticles were
    further investigated. Results: The results indicate that
    the 200-nm–sized MesoCS nanoparticles synthesized
    using a facile template method exhibited a high specific
    surface area and pore volume with internal mesopores
    (average pore size = 3.05 nm). Furthermore, the MesoCS
    nanoparticles can be used as drug carriers to maintain
    sustained release of gentamicin and fibroblast
    growth factor-2 (FGF-2). The MesoCS-loaded FGF-2
    might stimulate more odontogenic-related protein
    than CS because of the FGF-2 release. Conclusions:
    Based on this work, it can be inferred that MesoCS
    nanoparticles are potentially useful endodontic materials
    for biocompatible and osteogenic dental pulp tissue
    regenerative materials. (J Endod 2017;43:69–76)
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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