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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/102157


    Title: Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells.
    Authors: 魏宗德;Way, Tzong-Der;Hu, Chao-Ming;Hung, Chao-Ming;Li, Ying-Chao;Lin, Ying-Chao;Ho, Chi-Tang;Ho, Chi-Tang;Kao, Jung-Yie;Kao, Jung-Yie;魏宗德;Way, Tzong-Der;*
    Contributors: 保健營養生技學系
    Date: 2017
    Issue Date: 2017-03-01 14:06:30 (UTC+8)
    Abstract: Human epidermal growth factor receptor-2 (HER-2)-positive breast cancer tends to be aggressive, highly metastatic, and drug resistant and spreads rapidly. Studies have indicated that emodin inhibits HER-2 expression. This study compared the HER-2-inhibitory effects of two compounds extracted from rhubarb roots: aloe-emodin (AE) and rhein. Our results indicated that AE exerted the most potent inhibitory effect on HER-2 expression. Treatment of HER-2-overexpressing breast cancer cells with AE reduced tumor initiation, cell migration, and cell invasion. AE was able to suppress YB-1 expression, further suppressing downstream HER-2 expression. AE suppressed YB-1 expression through the inhibition of Twist in HER-2-overexpressing breast cancer cells. Our data also found that AE inhibited cancer metastasis and cancer stem cells through the inhibition of EMT. Interestingly, AE suppressed YB-1 expression through the downregulation of the intracellular integrin-linked kinase (ILK)/protein kinase B (Akt)/mTOR signaling pathway in HER-2-overexpressing breast cancer cells. In vivo study showed the positive result of antitumor activity of AE in nude mice injected with human HER-2-overexpressing breast cancer cells. These findings suggest the possible application of AE in the treatment of HER-2-positive breast cancer.
    Relation: Oncotarget
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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