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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/108083


    Title: Induction of neuroendocrine differentiation in castration resistant prostate cancer cells by adipocyte differentiation-related protein ;ADRP delivered by exosomes
    Authors: 林麗瓊;Lin LC;Gao AC;Lai CH;Hsieh JT;林赫;Lin Ho
    Contributors: 生物科技學系
    Date: 2017-04
    Issue Date: 2017-10-30 10:35:45 (UTC+8)
    Abstract: Although overall mortality rate of prostate cancer (PCa) declines in recent years, castration-resistant prostate cancer (CRPC) remains incurable. Clinical evidence indicates that CRPC recurred from hormonal therapy exhibits neuroendocrine differentiated (NED) phenotypes, which could contribute to therapeutic resistance and poor survival. Understanding the onset of NED could lead us to develop new therapeutic strategies for CRPC. Although PCa is known as a lipid-enriched tumor, its role in CRPC development is not fully understood. In this study, we demonstrated that IL-6 or androgen deprivation therapy (ADT)-induced lipid accumulation is associated with NED phenotypes. IL-6 or ADT can induce NED in PCa cells via peroxisome proliferator-activated receptor γ (PPARγ, a major lipogenic transcription factor) and adipocyte differentiation-related protein (ADRP, a major component of adiposome). In addition, ADRP protein can be detected in exosomes released from these cells and these exosomes are capable of inducing NED of PCa cells in a paracrine fashion. Understanding the role of PPARγ/ADRP in NED could provide new target(s) for CRPC therapy.
    Relation: CANCER LETTERS
    Appears in Collections:[生物科技學系] 期刊論文

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