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    题名: Platycodon grandiflorum ;PG reverses angiotensin II-induced apoptosis by repressing IGF-IIR expression
    作者: Yuan-Chuan L;Yuan-Chuan Lin;Chih-Hsueh L;Chih-Hsueh Lin;Hsien-Tsung;Hsien-Tsung Yao;Wei-Wen Kuo;Chia-Yao She;Chia-Yao Shen;Yu-Lan Yeh;Tsung-Jung H;Tsung-Jung Ho;V. Vijaya Pa;V. Vijaya Padma;Yu-Chen Lin;Chih-Yang Hu;Chih-Yang Huang;黃志揚;Chih-yang Huang
    贡献者: 生物科技學系
    日期: 2017-06
    上传时间: 2017-10-30 10:36:20 (UTC+8)
    摘要: Ethnopharmacological relevance

    Platycodon grandiflorum (PG) is a Chinese medical plant used for decades as a traditional prescription to eliminate phlegm, relieve cough, reduce inflammation and lower blood pressure. PG also has a significant effect on the cardiovascular systems.
    Materials and methods

    The aqueous extract of Platycodon grandiflorum (JACQ.) A. DC. root was screened for inhibiting Ang II-induced IGF-IIR activation and apoptosis pathway in H9c2 cardiomyocytes. The effects were also studied in spontaneously hypertensive rats (five groups, n=5) using low and high doses of PG for 50 days. The Ang II-induced IGF-IIR activation was analyzed by luciferase reporter, RT-PCR, western blot and surface IGF-IIR expression assay. Furthermore, the major active constituent of PG was carried out by high performance liquid chromatography-mass spectrometry (HPLC-MS).


    Our results indicate that a crude extract of PG significantly suppresses the Ang II-induced IGF-IIR signaling pathway to prevent cardiomyocyte apoptosis. PG extract inhibits Ang II-mediated JNK activation and SIRT1 degradation to reduce IGF-IIR activity. Moreover, PG maintains SIRT1 stability to enhance HSF1-mediated IGF-IIR suppression, which prevents cardiomyocyte apoptosis. In animal models, the administration of PG markedly reduced this apoptotic pathway in the heart of SHRs.


    Taken together, PG may be considered as an effective treatment for cardiac diseases in hypertensive patients.
    显示于类别:[生物科技學系] 期刊論文


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