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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/108150


    Title: WISP-1 positively regulates angiogenesis by controlling VEGF-A expression in human osteosarcoma
    Authors: Tsai HC;Tsai HC;Tzeng HE;Tzeng HE;Huang CY;Huang CY;黃元勵;HUANG, YUAN-LI;Tsai CH;Tsai CH;Wang SW;Wang SW;Wang PC;Wang PC;Chang AC;Chang AC;Fong YC;Fong YC;Tang CH;Tang CH
    Contributors: 生物科技學系
    Date: 2017
    Issue Date: 2017-10-30 10:41:28 (UTC+8)
    Abstract: In recent years, much research has focused on the role of angiogenesis in osteosarcoma, which occurs predominantly in adolescents and young adults. The vascular endothelial growth factor-A (VEGF-A) pathway is the key regulator of angiogenesis and in osteosarcoma. VEGF-A expression has been recognized as a prognostic marker in angiogenesis. Aberrant WNT1-inducible signaling pathway protein-1 (WISP-1) expression is associated with various cancers. However, the function of WISP-1 in osteosarcoma angiogenesis is poorly understood. We demonstrate a positive correlation between WISP-1 and VEGF-A expression in human osteosarcoma. Moreover, we show that WISP-1 promotes VEGF-A expression in human osteosarcoma cells, subsequently inducing human endothelial progenitor cell (EPC) migration and tube formation. The focal adhesion kinase (FAK), Jun amino-terminal kinase (JNK), and hypoxia-inducible factor (HIF)-1α signaling pathways were activated after WISP-1 stimulation, while FAK, JNK, and HIF-1α inhibitors or small interfering RNA (siRNA) abolished WISP-1-induced VEGF-A expression and angiogenesis. In vitro and in vivo studies revealed down-regulation of microRNA-381 (miR-381) in WISP-1-induced VEGF-A expression and angiogenesis. Our findings reveal that WISP-1 enhances VEGF-A expression and angiogenesis through the FAK/JNK/HIF-1α signaling pathways, as well as via down-regulation of miR-381 expression. WISP-1 may be a promising target in osteosarcoma angiogenesis.
    Relation: Cell Death & Disease
    Appears in Collections:[生物科技學系] 期刊論文

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