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    题名: Periostin promotes epithelial-mesenchymal transition via the MAPK/miR-381 axis in lung cancer
    作者: Wei-Wei Hu;陳?均;Po-Chun Cehn;Jun-Ming Che;Jun-Ming Chen;Yue-Ming Wu;Po-Yi Liu;Chih-Hao Lu;Yu-Feng Lin;湯智昕;Chih-Hsin Tang;Chia-Chia Ch;Chia-Chia Chao
    贡献者: 生物科技學系
    日期: 2017-07
    上传时间: 2017-10-30 10:43:03 (UTC+8)
    摘要: Periostin (POSTN, PN, or osteoblast-specific factor OSF-2) is a multifunctional
    cytokine that signals between the cell and the extracellular matrix. Periostin plays
    an important role in tumor development and is involved in carcinoma cell epithelialmesenchymal
    transition (EMT), whereby mature epithelial cells undergo phenotypic
    morphological changes and become invasive, motile cells. Here, we discuss the
    molecular mechanisms involved in periostin-induced promotion of EMT in lung cancer
    cells. Online TCGA datasets demonstrate the prognostic relevance of periostin in lung
    cancer; a higher periostin level correlates with poor overall survival. Similarly, our
    IHC results show that high periostin expression is positively correlated with the EMT
    markers Snail and Twist, as well as stage of lung cancer. We found that recombinant
    periostin induces the EMT phenotype in lung cancer cells through the p38/ERK pathway,
    while pretreatment with chemical inhibitors prevented periostin-induced EMT induction.
    Moreover, we found that periostin regulates EMT by repressing microRNA-381 (miR-
    381) expression, which targets both Snail and Twist. Using the miR-381 mimic, we
    dramatically reversed periostin-induced Snail and Twist expression. Furthermore,
    periostin knockdown dramatically affected EMT markers and cell migration potential.
    The role of periostin in lung cancer progression is elucidated by the in vivo mouse
    model. Our findings indicate that changes in periostin expression in lung cancer may
    serve as a therapeutic target for the treatment of lung cancer metastasis.
    關聯: Oncotarget
    显示于类别:[生物科技學系] 期刊論文


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