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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/108185


    Title: WISP-3 inhibition of miR-452 promotes VEGF-A expression in chondrosarcoma cells and induces endothelial progenitor cells angiogenesis.
    Authors: 林智暘;Chih-Yang Lin;Huey-En Tzen;Huey-En Tzeng;Te-Mao Li;Hsien-Te Che;Hsien-Te Chen;Yi Lee;Yi-Chen Yang;Shih-Wei Wan;Shih-Wei Wang8;Wei-Hung Yan;Wei-Hung Yang;湯智昕;Chih-Hsin Tang
    Contributors: 生物科技學系
    Date: 2017-04
    Issue Date: 2017-10-30 10:43:14 (UTC+8)
    Abstract: Chondrosarcoma is the second most prevalent general primary tumor of bone following osteosarcoma. Chondrosarcoma development may be linked to angiogenesis, which is principally elicited by vascular endothelial growth factor-A (VEGF-A). VEGF-A level has been recognized as a prognostic marker in angiogenesis. WNT1-inducible signaling pathway protein-3 (WISP)-3/CCN6 belongs to the CCN family and is involved in regulating several cellular functions, including cell proliferation, differentiation, and migration. Nevertheless, the effect of WISP-3 on VEGF-A production and angiogenesis in human chondrosarcoma remains largely unknown. This current study shows that WISP-3 promoted VEGF-A production and induced angiogenesis of human endothelial progenitor cells. Moreover, WISP-3-enhanced VEGF-A expression and angiogenesis involved the c-Src and p38 signaling pathways, while miR-452 expression was negatively affected by WISP-3 via the c-Src and p38 pathways. Our results illustrate the clinical significance of WISP-3, VEGF-A and miR-452 in human chondrosarcoma patients. WISP-3 may illustrate a novel therapeutic target in the metastasis and angiogenesis of chondrosarcoma.
    Relation: Oncotarget
    Appears in Collections:[生物科技學系] 期刊論文

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