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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/108267

    Title: The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes in Breast Cancer in Taiwan
    Authors: An-Kuo Chou;Chieh-Lun Hs;Chieh-Lun Hsiao;Tzu-Ching Sh;Tzu-Ching Shih;Hwei-Chung W;Hwei-Chung Wang;Chia-Wen Tsa;Chia-Wen Tsai;Wen-Shin Cha;Wen-Shin Chang;Liang-Chih L;Liang-Chih Liu;Tzong-Der Wa;Tzong-Der Way;Jing-Gung Ch;Jing-Gung Chung;包大?;Da-Tian Bau
    Contributors: 生物資訊與醫學工程學系
    Date: 2017-09
    Issue Date: 2017-11-03 14:05:42 (UTC+8)
    Abstract: Background/Aim: Metalloproteinases (MMPs) are
    a family of multifunctional proteins reported to be
    overexpressed in several types of cancers. However, the
    contribution of MMP8 genotype to oral cancer has not been
    elucidated. In this study, we focused on the contribution of
    polymorphisms in the promoter region of MMP-8 (C-799T)
    and two non-synonymous polymorphisms (Val436Ala and
    Lys460Thr) to Taiwanese oral cancer. Materials and Methods:
    In this case-control study, MMP-8 genotype, was examined
    among 788 patients with oral cancer and 956 gender- and
    age-matched healthy controls regarding its potential to
    determine oral cancer risk. Results: The distributions of
    MMP-8 C-799T, Val436Ala and Lys460Thr genotypes were
    not different between the oral cancer and non-cancer control
    groups. We also analyzed the allelic frequency distributions
    and no significant difference was found. As for geneenvironment
    interaction analysis, there was an increased risk
    for smokers, alcohol drinkers or betel quid chewers with
    variant MMP-8 C-799T or Val436Ala genotypes. Conclusion:
    Our findings suggest that the polymorphisms at MMP-8 C-
    799T or Val436Ala may not play a major role in mediating
    personal risk of oral cancer; however, the detailed
    mechanisms require further investigation.
    Oral cancer is the eighth most commonly diagnosed cancer
    worldwide and has the highest male incidence density in
    Taiwan (1-3). There is regional variation in trends of oral
    cancer around the world, depending on the etiology and the
    risk factors involved. According to the government annual
    report, oral cancer is the fourth cause of cancer-related death
    among males in Taiwan and has been reported to be closely
    associated with tobacco, alcohol and betel nut consumption
    habits (4-7). In the past years, genomic biomarkers for oral
    cancer in Taiwan have been revealed (8-14) and further
    cellular etiological investigations and the interactions among
    the genetic and lifestyle factors will contribute to
    personalized cancer early detection and therapy.
    Matrix metalloproteinases (MMPs), also known as
    matrixins, are a family of calcium-dependent zinc-containing
    endopeptidases that play a key role in extracellular matrix
    homeostasis controlling the degradation of the components
    of connective tissue matrices (15, 16). In carcinogenesis,
    MMPs and their inhibitors are also related to the regulation
    of oral cancer invasion and metastasis (17-20). The
    imbalance of these MMPs and their interactions with specific
    inhibitors, e.g. the tissue inhibitors of metalloproteinases
    (TIMPs), may contribute to the initiation and progression of
    cancer (16, 17, 21). MMP-8, originally known as neutrophil
    collagenase, is expressed in not only neutrophils but also
    epithelial cells, fibroblasts, macrophages and endothelial
    cells (22-24). In recent years, mounting evidence showed
    that MMP-8 was capable to conduct cancer- and metastasissuppressive
    activities. Firstly, knockout of MMP induced a
    dramatic increase in the incidence of carcinogen-induced
    This article is freely accessible online.
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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