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    题名: Autophagy-inducing effect of pterostilbene: A prospective therapeutic/preventive option for skin diseases.
    作者: Wang, 陳容甄;Rong-Jane Chen;李宥萱;Yu-Hsuan Lee;葉雅玲;Ya-Ling Yeh;吳玟萱;Wun-Syuan Wu;何其儻;Chi-Tang Ho;利佳怡;Chia-Yi Li;王伯智;Bour-Jr Wang;王應然;Ying-Jan
    贡献者: 生物資訊與醫學工程學系
    日期: 2017
    上传时间: 2017-11-03 14:07:02 (UTC+8)
    摘要: Pterostilbene is a naturally occurring analog of resveratrol with many health benefits. These health benefits are associated with its antioxidant activity, anti-inflammatory effects, and chemopreventive effects attributed to its unique structure. The skin cancer chemopreventive potential of pterostilbene is supported by a variety of mechanistic studies confirming the anti-inflammatory effects in skin cancer models. Molecular biological studies have identified that pterostilbene targets pleotropic signaling pathways, including those involved in mitogenesis, cell cycle regulation, and apoptosis. Recently, pterostilbene has been reported to induce autophagy in cancer and normal cells. Through autophagy induction, the inflammatory-related skin diseases can be attenuated. This finding suggests the potential use of pterostilbene in the treatment and prevention of skin disorders via alleviating inflammatory responses by autophagy induction. This review summarizes the protective and therapeutic benefits of pterostilbene in skin diseases from the viewpoint of its antioxidant, anti-inflammatory, and autophagy-inducing effects. Novel underlying mechanisms regarding these effects are discussed. We proposed that pterostilbene, a promising natural product, can be used as a preventive and therapeutic agent for inflammation-related skin disorders through induction of autophagy.
    關聯: JOURNAL OF FOOD AND DRUG ANALYSIS
    显示于类别:[生物資訊與醫學工程學系 ] 期刊論文

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