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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/108311

    Title: Immunohistochemical biomarkers and volumetric parameters for predicting radiotherapy-based outcomes in patients with p16-negative pharyngeal cancer
    Authors: 陳芮筠;Rui-Yun Chen;Ying-Chun Li;Ying-Chun Lin;Shang-Wen Ch;Shang-Wen Chen;Tze-Yi Lin;Te-Chun Hsie;Te-Chun Hsieh;Kuo-Yang Yen;Ji-An Liang;Shih-Neng Ya;Shih-Neng Yang;Yao-Ching Wa;Yao-Ching Wang;Ya-Huey Chen;Shu-Fen Chia;Shu-Fen Chiang;高嘉鴻;Chia-Hung Kao
    Contributors: 生物資訊與醫學工程學系
    Date: 2017-08
    Issue Date: 2017-11-03 14:08:37 (UTC+8)
    Abstract: Background

    This study determined the prognostic effects of immunohistochemical biomarkers and volumetric parameters predicting radiotherapy-based treatment in patients with p16-negative squamous cell carcinoma of the oropharynx or hypopharynx.


    VEGF immunoreactivity > 2 and GLUT1 overexpression were prognostic factors for lower cause-specific survival. Moreover, both factors were associated with lower disease-free survival. The predictors of lower primary relapse-free survival were VEGF immunoreactivity > 2 and CT-based gross tumor volume > 16 mL.

    Materials and Methods

    Immunohistochemical biomarkers in pretreatment biopsy specimens from 60 patients with p16-negative cancer were analyzed using tissue microarrays. Computed tomography (CT)-based and biological tumor volumes were retrieved through fluorodeoxyglucose positron emission tomography-CT. Correlations of cause-specific, disease-free, and primary relapse-free survival with volumetric parameters and the immunohistochemical biomarker score were investigated.


    For patients with p16-negative pharyngeal cancer receiving radiotherapy, treatment outcomes can be stratified by VEGF and GLUT1 expression and CT-based gross tumor volume.

    Keywords: squamous cell carcinoma, p16-negative pharyngeal cancer, biomarker, positron emission tomography–computed tomography, gross tumor volume
    Relation: Oncotarget
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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