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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/108316


    Title: Association of Interleukin-12A rs568408 with Susceptibility to Asthma in Taiwan
    Authors: 沈德群;Te-Chun Shen;Chia-Wen Tsa;Chia-Wen Tsai;Wen-Shin Cha;Wen-Shin Chang;Shengyu Wang;Che-Yi Chao;Chieh-Lun Hs;Chieh-Lun Hsiao;Wei-Chun Che;Wei-Chun Chen;Te-Chun Hsia;包大?;Da-Tian Bau
    Contributors: 生物資訊與醫學工程學系
    Date: 2017-06
    Issue Date: 2017-11-03 14:08:58 (UTC+8)
    Abstract: Asthma is an inflammatory disease and interleukin 12 (IL-12) may play a regulatory role in allergen-induced inflammation. The aim of this study was to investigate the association of polymorphisms in IL-12A/IL-12B with asthma. The asthma group included 198 adult patients and the control group included 453 individuals without asthma that were frequency-matched by gender and age. The distribution of genotypic and allelic frequencies of IL-12A rs568408 demonstrated significant differences between case and control groups. Specifically, the percentages of AA genotype of IL-12A rs568408 was significantly higher among asthmatic patients in Taiwan than healthy controls, compared to GG genotype. No significant difference was observed among the IL-12A rs2243115 and IL-12B rs3212227 genotypes between case and control groups. In addition, the A allele at IL-12A rs568408 was associated with more severe symptoms (P = 0.0085) among asthmatic patients. These results suggest that IL-12A rs568408 may contribute to the etiology and symptoms severity of asthma, indicating its usefulness as a predictive and diagnostic biomarker of asthma.
    Relation: Scientific Reports
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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