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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/108400

    Title: A study to evaluate the potential of an in silico approach for predicting dipeptidyl peptidase-IV inhibitory activity in vitro of protein hydrolysates
    Authors: 王子源;Tzu-Yuan Wang;謝承紘;Cheng-Hong Hsieh;洪娟娟;Hung Chuan-Chuan;饒家麟;Chia-Ling Jao;林佩儀;Pei-Yi Lin;謝宥諒;You-Liang Hsieh;徐國強;Hsu Kuo-Chiang
    Contributors: 保健營養生技學系
    Date: 2017-11
    Issue Date: 2017-12-08 14:10:42 (UTC+8)
    Abstract: A total of 294 edible protein sequences and 5 commercial proteases listed in the BIOPEP database were analyzed in silico. The frequency (A), a parameter in silico described previously, was examined further to calculating the ratio of truncated peptides with Xaa-proline and/or Xaa-alanine to all peptide fragments in a protein hydrolyzed with a protease, using the BIOPEP database. Then the in vitro DPP-IV inhibitory activity was determined using the same 15 protein and protease combinations to evaluate their relationship. The result shows that A values considering the number of Xaa-proline + Xaa-alanine exhibited a strong correlation with in vitro DPP-IV inhibition rates by Pearson’s correlation analysis (r = 0.6993; P < 0.05). Therefore, the in silico approach is effective to predict DPP-IV inhibitory activities in vitro of protein hydrolysates.
    Relation: FOOD CHEMISTRY
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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