ASIA unversity:Item 310904400/108421
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    题名: Aloe-emodin inhibits HER-2 expression through the downregulation of Y-box binding protein-1 in HER-2-overexpressing human breast cancer cells.
    作者: Way, 魏宗德；Tzong-Der Way；Chao-Ming Hu；Chao-Ming Hung；Ying-Chao Li；Ying-Chao Lin；Chi-Tang Ho；Chi-Tang Ho；Jung-Yie Kao；Jung-Yie Kao；魏宗德；Tzong-Der
    贡献者: 保健營養生技學系
    日期: 2017
    上传时间: 2017-12-08 14:12:06 (UTC+8)
    摘要: Human epidermal growth factor receptor-2 (HER-2)-positive breast cancer tends to be aggressive, highly metastatic, and drug resistant and spreads rapidly. Studies have indicated that emodin inhibits HER-2 expression. This study compared the HER-2-inhibitory effects of two compounds extracted from rhubarb roots: aloe-emodin (AE) and rhein. Our results indicated that AE exerted the most potent inhibitory effect on HER-2 expression. Treatment of HER-2-overexpressing breast cancer cells with AE reduced tumor initiation, cell migration, and cell invasion. AE was able to suppress YB-1 expression, further suppressing downstream HER-2 expression. AE suppressed YB-1 expression through the inhibition of Twist in HER-2-overexpressing breast cancer cells. Our data also found that AE inhibited cancer metastasis and cancer stem cells through the inhibition of EMT. Interestingly, AE suppressed YB-1 expression through the downregulation of the intracellular integrin-linked kinase (ILK)/protein kinase B (Akt)/mTOR signaling pathway in HER-2-overexpressing breast cancer cells. In vivo study showed the positive result of antitumor activity of AE in nude mice injected with human HER-2-overexpressing breast cancer cells. These findings suggest the possible application of AE in the treatment of HER-2-positive breast cancer.
    關聯: Oncotarget
    显示于类别:[食品營養與保健生技學系] 期刊論文

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