Objective Chronic obstructive pulmonary disease (COPD)
and benign prostatic hyperplasia (BPH) are common
disorders in ageing male populations. Nevertheless, the
relationship between the two diseases has rarely been
explored. The objective of this study was to examine
whether patients with COPD are at an increased risk of
Design Retrospective nationwide cohort study.
Setting Data retrieved from the Taiwan National Health
Insurance Research Database.
Participants Overall, 19 959 male patients aged 40
years and over with newly diagnosed COPD between 2000
and 2006 were included as the COPD group, and 19 959
sex-matched and age-matched enrollees without COPD
were included as the non-COPD group. Both groups were
followed-up until the end of 2011.
Outcome measures A Cox proportional hazards
regression model was used to compute the risk of BPH
in patients with COPD compared with enrollees without
Results The overall incidence rate of BPH was 1.53
times higher in the COPD group than that in the nonCOPD
group (44.7 vs 25.7 per 1000 person-years, 95% CI
1.46 to 1.60) after adjusting for covariates. An additional
stratified analysis revealed that this increased risk of BPH
in patients with COPD remained significantly higher than
that in enrollees without COPD in all men aged 40 years
Conclusion After adjustment for covariates, male patients
with COPD were found to be at a higher risk of BPH.
We suggest that clinicians should be cautious about the
increased risk of BPH in male patients with COPD.