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http://asiair.asia.edu.tw/ir/handle/310904400/110721
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Title: | FSCN1 gene polymorphisms: biomarkers for the development and progression of breast cancer. |
Authors: | Wan, Chao-Qun;Wang, Chao-Qun;湯智昕;Tang, Chih-Hsin;Wang, Yan;Jin, Lulu;Wang, Qian;Li, Xiaoni;Hu, Gui-Nv;Huang, Bi-Fei;Zh, Yong-Ming;Zhao, Yong-Ming;Su, Chen-Ming |
Contributors: | 生物科技學系 |
Date: | 2017-11 |
Issue Date: | 2018-04-03 09:14:15 (UTC+8) |
Abstract: | Breast cancer is a major cause of cancer mortality worldwide. Fascin-1 (FSCN1) is an actin-binding
protein found in mammalian cells, including endothelial, neuronal and mesenchymal cells. FSCN1
overexpression has been indicated in breast cancer patients. However, scant information is available
regarding the association between FSCN1 single nucleotide polymorphisms (SNPs) and the risk
or prognosis of breast cancer. We report on the association between 6 SNPs of the FSCN1 gene
(rs56156320, rs8772, rs3801004, rs2966447, rs852479 and rs1640233) and breast cancer susceptibility
as well as clinical outcomes in 316 patients with breast cancer and in 222 healthy controls. Carriers of
the AC or AC+CC allele of the variant rs56156320 were at greater risk of breast cancer compared with
wild-type (AA) carriers. Moreover, carriers of at least one G allele in rs3801004 were likely to progress
to stage III/IV disease and lymph node metastasis. Individuals with at least one T allele at FSCN1 SNP
rs2966447 were at higher risk of developing pathologic grade G3 disease. Furthermore, individuals
bearing the C/C haplotype at SNPs rs56156320 and rs3801004 had nearly twice the risk of breast cancer.
Our results indicate that genetic variations in the FSCN1 gene may serve as an important predictor of
early-stage breast cancer. |
Relation: | Scientific Reports |
Appears in Collections: | [生物科技學系] 期刊論文
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