English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90570/105786 (86%)
Visitors : 16398746      Online Users : 322
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/110723

    Title: Tanshinone IIA inhibits angiogenesis in human endothelial progenitor cells in vitro and in vivo
    Authors: 李湘萍;Lee, Hsiang-Ping;Yueh-Ching, L;Liu, Yueh-Ching;陳?均;Cehn, Po-Chun;Huai-Ching, T;Tai, Huai-Ching;Li, Te-Mao;Fong, Yi-Chin;Chih-Shiang;Chang, Chih-Shiang;Wu, Min-Huan;Chiu, Li-Pin;Wa, Chia-Jung;Wang, Chia-Jung;Che, Yi-Hsuan;Chen, Yi-Hsuan;Wu, Yih-Jer;湯智昕;Tang, Chih-Hsin;Wan, Shih-Wei;Wang, Shih-Wei
    Contributors: 生物科技學系
    Date: 2017-11
    Issue Date: 2018-04-03 09:14:23 (UTC+8)
    Abstract: Accumulating evidence reports that bone marrow-derived endothelial progenitor cells (EPCs) regulate angiogenesis, postnatal neovascularization and tumor metastasis. It has been suggested that understanding the molecular targets and pharmacological functions of natural products is important for novel drug discovery. Tanshinone IIA is a major diterpene quinone compound isolated from Danshen (Salvia miltiorrhiza) and is widely used in traditional Chinese medicine (TCM). Evidence indicates that tanshinone IIA modulates angiogenic functions in human umbilical vein endothelial cells. However, the anti-angiogenic activity of tanshinone IIA in human EPCs has not been addressed. Here, we report that tanshinone IIA dramatically suppresses vascular endothelial growth factor (VEGF)-promoted migration and tube formation of human EPCs, without cytotoxic effects. We also show that tanshinone IIA markedly inhibits VEGF-induced angiogenesis in the chick embryo chorioallantoic membrane (CAM) model. Importantly, tanshinone IIA significantly attenuated microvessel formation and the expression of EPC-specific markers in the in vivo Matrigel plug assay in mice. Further, we found that tanshinone IIA inhibits EPC angiogenesis through the PLC, Akt and JNK signaling pathways. Our report is the first to reveal that tanshinone IIA reduces EPC angiogenesis both in vitro and in vivo. Tanshinone IIA is a promising natural product worthy of further development for the treatment of cancer and other angiogenesis-related pathologies.
    Relation: Oncotarget
    Appears in Collections:[生物科技學系] 期刊論文

    Files in This Item:

    File SizeFormat

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback