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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/110749


    Title: The Association of Flap Endonuclease 1 Genotypes with the Susceptibility of Endometriosis
    Authors: 周安國;Chou, An-Kuo;Shen, Ming-Yi;Chen, Fang-Yu;Hs, Chieh-Lun;Hsiao, Chieh-Lun;Liang-Chun, S;Shih, Liang-Chun;Cha, Wen-Shin;Chang, Wen-Shin;Tsa, Chia-Wen;Tsai, Chia-Wen;Yin, Tsung-Ho;Ying, Tsung-Ho;Ming-Hsien, W;Wu, Ming-Hsien;Hua, Chung-Yu;Huang, Chung-Yu;包大?;Bau, Da-Tian
    Contributors: 生物資訊與醫學工程學系
    Date: 2017-11
    Issue Date: 2018-04-03 09:16:18 (UTC+8)
    Abstract: Background/Aim: Flap endonuclease 1 (FEN1),
    a protein with multiple functions in genome stability
    maintenance, is important in cancer prevention. The two
    functional germline variants of FEN1, rs174538 and
    rs4246215, regarding cancer susceptibility have been
    reported in lung, breast, liver, esophageal, gastric, colorectal
    cancer, glioma and leukemia, but not endometriosis. In this
    study, we firstly aimed at evaluating the contribution of
    FEN1 genotypes to endometriosis risk in a representative
    Taiwan population. Materials and Methods: In total, 153
    patients with endometriosis and 636 non-cancer healthy
    controls were genotyped by polymerase chain reactionrestriction
    fragment length polymorphism (PCR-RFLP)
    methodology. Results: The genotypes of FEN1 rs174538, but
    not those of rs4246215, were differently distributed between
    the endometriosis and control groups. In detail, the AA of
    FEN1 rs174538 genotypes were significantly less frequently
    found among endometriosis patients than among controls
    (odds ratio [OR]=0.43, 95% confidence interval [CI]=0.24-
    0.78, p=0.0125). The A allele at FEN1 rs174538 was also
    significantly less frequent among cases than controls
    (OR=0.65, 95%CI=0.50-0.86, p=0.0021). As for age of first
    menarche, those with first menarche at the age >12.8
    carrying the FEN1 rs174538 AA genotype conferred lower
    OR of 0.29 (95%CI=0.11-0.78, p=0.0381) for endometriosis.
    Regarding the full pregnancy status, those without having
    had a full-term pregnancy carrying the FEN1 rs174538 AA
    genotype were of lower risk (ORs=0.12, 95%CI=0.03-0.53,
    p=0.0050). Conclusion: The FEN1 rs174538 A allele is a
    novel protective biomarker for endometriosis and this
    genotype may have interactions with age- and hormonerelated
    factors on the development of endometriosis.
    Relation: Cancer Genomics & Proteomics
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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