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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/110764


    Title: S-allylcysteine Improves Blood Flow Recovery and Prevents Ischemic Injury by Augmenting Neovasculogenesis
    Authors: Syu, Jia-Ning;Yang, Mei-Due;蔡淑瑤;Tsai, Shu-Yao;Isabe, En-Pei;Chiang, En-Pei Isabel;Ch, Shao-Chih;Chiu, Shao-Chih;趙哲毅;Chao, Che-Yi;Raymond, L. R;Rodriguez, Raymond L.;Tan, Feng-Yao;Tang, Feng-Yao
    Contributors: 食品營養與保健生技學系
    Date: 2017-10
    Issue Date: 2018-04-03 09:25:09 (UTC+8)
    Abstract: Studies suggest that a low level of circulating human endothelial progenitor cells (EPCs) is a risk factor for ischemic injury and coronary artery disease (CAD). Consumption of S-allylcysteine (SAC) is known to prevent CAD. However, the protective effects of SAC on the ischemic injury are not yet clear. In this study, we examined whether SAC could improve blood flow recovery in ischemic tissues through EPC-mediated neovasculogenesis. The results demonstrate that SAC significantly enhances the neovasculogenesis of EPCs in vitro. The molecular mechanisms for SAC enhancement of neovasculogenesis include the activation of Akt/endothelial nitric oxide synthase signaling cascades. SAC increased the expression of c-kit, β-catenin, cyclin D1, and Cyclin-dependent kinase 4 (CDK4) proteins in EPCs. Daily intake of SAC at dosages of 0.2 and 2 mg/kg body weight significantly enhanced c-kit protein levels in vivo. We conclude that dietary consumption of SAC improves blood flow recovery and prevents ischemic injury by inducing neovasculogenesis in experimental models.

    Keywords: S-allylcysteine, neovascularization, c-kit, Akt, human endothelial progenitor cells
    Relation: CELL TRANSPLANTATION
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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