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    题名: The antioxidant activity and nitric oxide production of extracts obtained from the leaves of Chenopodium quinoa Willd
    作者: 陳曉鈴;Chen, Hsiao-ling;Xiang-Zhen, L;Lan, Xiang-Zhen;Wu, Yan-Yi;Ou, Yu-Wen;陳宗祺;Chen, Tsung-Chi;吳文慈;Wu, Wen-Tzu
    贡献者: 食品營養與保健生技學系
    日期: 2017-12
    上传时间: 2018-04-03 09:25:13 (UTC+8)
    摘要: Background: Most reports have indicated the antioxidant capacity of quinoa seeds. However, the leaves of Quinoa (Chenopodium quinoa Willd.) are usually worthless and little known about their biological activities. In this study, the antioxidant and immunomodulatory potential of the quinoa leaf extracts were explored.

    Methods: The crude leaf extracts of quinoa were extracted using water, 50% ethanol or 95% ethanol as solvent, denoted WQL, 50% EQL and 95% EQL, respectively. The antioxidant activities of quinoa leaf extracts were assessed by the ability of 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging and iron chelating. The total phenolic content was determined. Inhibition of nitric oxide (NO) production in the lipopolysaccharide (LPS)-induced murine macrophage RAW 264.7 cells was examined to gauge the anti-inflammatory activity.

    Results: The 95% EQL showed a higher level of total phenolic content (569.5 mg GAE/g extract) and better DPPH scavenging activity. The WQL exhibited a better iron chelating capacity (28.9% at 10 mg/ml). The iron chelating activity of the 95% EQL increased in a concentration-dependent manner, which ranged from 10.9% up to 53.9%. The 50% EQL and 95% EQL significantly inhibited NO production in the LPSstimulated RAW 264.7 cells.

    Conclusion: We demonstrate that the extracts of quinoa leaves possess the biological activities of antioxidant and anti-inflammatory. Our finding suggests that the leaf extract of quinoa has potential to be utilized for natural health products.

    Keywords: Chenopodium quinoa, Antioxidant activity, Nitric oxide
    關聯: BioMedicine
    显示于类别:[食品營養與保健生技學系] 期刊論文

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