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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/110964

    Title: 女性嚼食檳榔非飲酒者之肝硬化勝算比高於男性
    Authors: 朱裕華
    Contributors: 健康產業管理學系健康管理組
    Keywords: 肝硬化、檳榔、非飲酒者、公共衛生、台灣、cirrhosis、betel nut、non-alcohol drinker、public health、Taiwan
    Date: 2018
    Issue Date: 2018-06-14 14:44:49 (UTC+8)
    Publisher: 亞洲大學
    Abstract: 背景與目的:

    飲酒者中嚼食檳榔與肝硬化的已有明確的相關。 然而,很少有研究探討非飲酒者的嚼食檳榔與肝硬化是否有相關存在。 本研究目的是探討非飲酒者的嚼食檳榔和肝硬化間勝算比的相關。


    本研究回顧分析了2012年成人預防醫療服務和台灣國民健康保險研究數據庫的數據。 參與者的信息包括體檢和生活方式,以及實驗室檢查的數據。 嚼食檳榔者分為三類:從不,偶爾和常常嚼食檳榔。 採用國際疾病分類第九版臨床修改(ICD-9-CM)診斷疾病。 最初2012年收集成人免費預防醫療服務的1,573,024名40歲以上的成年人。 但是,只有1,065,246人被納入分析。 統計分析採用卡方檢定和邏吉斯迴歸分析。


    經多變量分析調整後,兩性的肝硬化和嚼食檳榔存在顯著的相關性(p趨勢檢定<0.0001)。 女性嚼食檳榔者的肝硬化危險性高於男性。 偶爾和常常嚼食檳榔女性肝硬化的勝算比分別為2.91(95%C.I.:1.75-4.83); 3.06(95%C.I.:1.69-5) 。 但是,在偶爾和常常檳榔
    嚼食的男的勝算比分別是1.76(95%C.I.:1.47-2.10) 和2.32 (95%C.I.:1.90-2.85) 。



    Background and Aim:

    The association of betel nut with liver cirrhosis among alcohol drinkers has been clearly shown. However, very scare studies have shown such an association among non-alcohol drinkers. The aim of this study was to assess the relationship between betel nut chewing and cirrhosis among non-alcohol drinkers.

    Materials and Methods:

    This study retrospectively analyzed data retrieved from the 2012 Adult Preventive Medical Services and the National Health Insurance Research Datasets in Taiwan. Participants’ information included physical examination and lifestyle, alongside laboratory tests. Betel nut chewers were grouped into three categories: never, occasional and frequent. Diseases were diagnosed using the International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM). Initially, 1573024 adults aged 40 years and above who engaged in the free adult preventive medical services in 2012 were recruited. However, only 1065246 of them were included in the analysis. Chi-square test and logistic regression were used for the analyses.


    After multivariable adjustments, there were significant relationships between cirrhosis and betel nut chewing in both gender (p-trend < 0.0001).The risk of cirrhosis was greater in females than males. The odds ratio of cirrhosis in occasional and frequent female chewers were respectively 2.91; 95% C.I: 1.75–4.83 and 3.06; 95% C.I: 1.69–5. However, they were 1.76; 95% C.I: 1.47–2.10 and 2.32; 95% C.I: 1.90–2.85 in occasional and frequent male chewers respectively.


    This study demonstrated significant relationships between betel nut chewing and cirrhosis in both male and female non-alcohol drinkers. The risk of cirrhosis was greater in female than male chewers.
    Appears in Collections:[健康產業管理學系] 博碩士論文

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