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|Title: ||Increased Calcitonin Gene-Related Peptide and Macrophages Are Involved in Astragalus membranaceus-Mediated Peripheral Nerve Regeneration in Rats|
|Authors: ||Chung-Chia, Chung-Chia C;Chen, Chung-Chia;Ling-Chuan, Chuan C;Chang, Ling-Chuan;姚俊旭;Yao, Chun-Hsu;Hsu, Yuan-Man;Hsu, Yuan-Man;林佳弘;Lin, Jia-Horng;Yang, Tse-Yen;Yang, Tse-Yen;陳永祥;Chen, Yung-Hsian;陳悅生;Chen, Yueh-Sheng;*|
|Issue Date: ||2018-08-16 11:33:30 (UTC+8)|
|Abstract: ||Astragalus membranaceus (AM) is one of 50 fundamental herbs in traditional Chinese medicine. Previous studies have shown that AM extract can be a potential nerve growth-promoting factor, being beneficial for the growth of peripheral nerve axons. We further investigated the effects of AM extract on regeneration in a rat sciatic nerve transection model. Rats were divided into three groups ([Formula: see text]): normal saline (intraperitoneal) as the control, and 1.5[Formula: see text]g/kg or 3.0[Formula: see text]g/kg of AM extract (every other day for four weeks), respectively. We evaluated neuronal electrophysiology, neuronal connectivity, macrophage infiltration, expression levels and location of calcitonin gene-related peptide (CGRP), and expression levels of both nerve growth factors (NGFs) and immunoregulatory factors. In the high-dose AM group, neuronal electrophysiological function (measured by nerve conductive velocity and its latency) was significantly improved ([Formula: see text]). Expression levels of CGRP and macrophage density were also drastically enhanced ([Formula: see text]). Expression levels of fibroblast growth factor (FGF), NGF, platelet-derived growth factor (PDGF), transforming growth factor-[Formula: see text], interleukin-1 (IL-1), and interferon (IFN)-[Formula: see text] were reduced in the high-dose AM group ([Formula: see text]), while FGF, NGF, PDGF, IL-1, and IFN-[Formula: see text] were increased in the low-dose AM group ([Formula: see text]). These results suggest that AM can modulate local inflammatory conditions, enhance nerve regeneration, and potentially increase recovery of a severe peripheral nerve injury.|
|Relation: ||AMERICAN JOURNAL OF CHINESE MEDICINE|
|Appears in Collections:||[心理學系] 期刊論文|
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