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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111350

    Title: A controlled trial of Sheng-Yu-Tang for post-hematopoietic stem cell transplantation leukemia patients: A proposed protocol and insights from a preliminary pilot study
    Authors: 馮堂正;Fleischer, Tom;張東迪;Chang, Tung-Ti;蔣仁槐;Chiang, Jen-Huai;顏宏融;Yen, Hung-Rong;*
    Contributors: 生物科技學系
    Date: 2018-01
    Issue Date: 2018-08-20 09:44:24 (UTC+8)
    Abstract: Introduction: Hematopoietic stem cell transplantation has become a well-established treatment for hematologic disorders including acute leukemia. However, long-term survival rates following this procedure are still extremely low, due to posttransplantation relapse, infections, and graft-versus-host disease. We propose that adjunctive Chinese herbal medicine may benefit posttransplantation patients. In preparation for a randomized clinical trial, we conducted a pilot trial. Methods and Analysis: Between September 2015 and June 2017, 18 patients were consecutively enrolled at China Medical University Hospital and followed for up to 1 year. Fresh blood samples were obtained on a monthly basis, and immune reconstitution was analyzed. In addition to the standard-care treatment administered by their oncologist, a number of patients also received a Chinese herbal formula (Sheng-Yu-Tang) for up to 6 months. Results were used to improve on study protocol and estimate required sample size for a future randomized trial. Ethics and Dissemination: Study protocol was approved by the institutional review board of China Medical University Hospital (DMR-105-005), and all participants provided informed consent.

    Keywords HSCT, acute leukemia, immune reconstitution, Chinese herbal medicine
    Appears in Collections:[生物科技學系] 期刊論文

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