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|Title: ||Variations in the AURKA Gene: Biomarkers for the Development and Progression of Hepatocellular Carcinoma|
|Authors: ||Wang, Bin;Wang, Bin;Hs, Chin-Jung;Hsu, Chin-Jung;Chia-Hsuan, Chia-Hsuan C;Chou, Chia-Hsuan;Hsiang-Lin, Lin L;Lee, Hsiang-Lin;Ch, Whei-Ling;Chiang, Whei-Ling;Su, Chen-Ming;Su, Chen-Ming;Ts, Hsiao-Chi;Tsai, Hsiao-Chi;Yang, Shun-Fa;Yang, Shun-Fa;湯智昕;Chih-Hsin, Tang;*|
|Issue Date: ||2018-08-20 09:44:43 (UTC+8)|
|Abstract: ||Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. AURKA (aurora kinase A) is a mitotic serine/threonine kinase that functions as an oncogene and plays a critical role in hepatocarcinogenesis. We report on the association between 4 single nucleotide polymorphisms (SNPs) of the AURKA gene (rs1047972, rs2273535, rs2064836, and rs6024836) and HCC susceptibility as well as clinical outcomes in 312 patients with HCC and in 624 cancer-free controls. We found that carriers of the TT allele of the variant rs1047972 were at greater risk of HCC compared with wild-type (CC) carriers. Moreover, carriers of at least one A allele in rs2273535 were less likely to progress to stage III/IV disease, develop large tumors or be classified into Child-Pugh class B or C. Individuals with at least one G allele at AURKA SNP rs2064863 were at lower risk of developing large tumors or progressing to Child-Pugh grade B or C. Our results indicate that genetic variations in the AURKA gene may serve as an important predictor of early-stage HCC and be a reliable biomarker for the development of HCC.
Keywords: AURKA polymorphisms, Hepatocellular carcinoma, Single nucleotide polymorphism, Susceptibility.
|Relation: ||International Journal of Medical Sciences|
|Appears in Collections:||[生物科技學系] 期刊論文|
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