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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111357


    Title: Associations of Tumor PD-1 Ligands, Immunohistochemical Studies, and Textural Features in 18F-FDG PET in Squamous Cell Carcinoma of the Head and Neck
    Authors: Chen, Rui-Yun;Chen, Rui-Yun;Li, Ying-Chun;Lin, Ying-Chun;She, Wei-Chih;Shen, Wei-Chih;Hsie, Te-Chun;Hsieh, Te-Chun;Yen, Kuo-Yang;Yen, Kuo-Yang;Ch, Shang-Wen;Chen, Shang-Wen;高嘉鴻;Kao, Chia-Hung;*
    Contributors: 生物資訊與醫學工程學系
    Date: 2018-01
    Issue Date: 2018-08-20 09:45:16 (UTC+8)
    Abstract: To know tumor PD-L1 expression through IHC or the FDG-PET related radiomics, we investigated the association between programmed cell death protein 1 ligand (PD-L1) expression and immunohistochemical (IHC) biomarkers or textural features of 18F-fluoro-2-deoxdeoxyglucose positron emission tomography (18F-FDG PET) in 53 oropharyngeal or hypopharyngeal cancer patients who were ready to undergo radiotherapy-based treatment. Differences in textural features or biomarkers between tumors with and without PD-L1 expression were tested using a Mann–Whitney U test. The predicted values for PD-L1 expression were examined using logistic regression analysis. The mean percentages of tumor PD-L1 expression were 6.2 ± 13.5. Eighteen tumors had PD-L1 expression ≥5%, whereas 30 tumors ≥1%. Using a 5% cutoff, the p16 staining percentage and the textural index of correlation were two factors associated with PD-L1 expression. The odds ratios (ORs) were 17.00 (p = 0.028) and 0.009 (p = 0.015), respectively. When dichotomizing PD-L1 at 1%, the p16 and Ki-67 staining percentages were two predictors for PD-L1 expression with ORs of 11.41 (p = 0.035) and 757.77 (p = 0.045). p16 and Ki-67 staining percentages and several PET/CT-derived textural features can provide supplemental information to determine tumor PD-L1 expression in HNCs.
    Relation: Scientific Reports
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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