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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111375

    Title: Preventive Effects of Velvet Antler (Cervus elaphus)against Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting MAPK/NF-κB Activation and Inducing AMPK/Nrf2 Pathways.
    Authors: Chan, Jui-Shu;Chang, Jui-Shu;Lin, Hung-Je;Lin, Hung-Jen;鄧正賢;Deng, Jeng-Shyan;Wu, Wen-Tzu;Wu, Wen-Tzu;Huang, Guan-;Huang, Guan-Jhong;*
    Contributors: 食品營養與保健生技學系
    Date: 2018-01
    Issue Date: 2018-08-20 09:48:04 (UTC+8)
    Abstract: Introduction

    Acute lung injury (ALI) is the most common form of
    respiratory failure, which is shown by increasing capillaryalveolar
    permeability, changing in lung protein leaks, infammatory
    cell accumulation, interstitial edema, disruption of
    the alveolar epithelium, excessive polymorphonuclear neutrophil
    (PMN) migration, and the release of proinfammatory
    cytokines and mediators in the lung [1]. Tis disease is
    associated with a great risk of morbidity and mortality in
    patients with shock, sepsis, ischemia-reperfusion, aspiration
    of gastric contents, major trauma, and other clinical
    disorders [2]. Macrophages can be activated by cytokines
    such as interferon-� (IFN-�) and lipopolysaccharide (LPS,
    bacterial endotoxin) and downregulation of proinfammatory
    cytokine release [tumor necrosis factor-alpha (TNF-�),
    interleukin-1� (IL-1�), and IL-6] and infammatory factors
    (NO) that recruit additional immune cells to the tissue
    injury [3, 4]. Also, LPS promotes the production of reactive
    oxygen species (ROS) and reactive nitrogen species (RNS).
    Relation: Evidence-based Complementary and Alternative Medicine
    Appears in Collections:[食品營養與保健生技學系] 期刊論文

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