ASIA unversity:Item 310904400/111463
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 90120/105277 (86%)
造访人次 : 8144246      在线人数 : 2036
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://asiair.asia.edu.tw/ir/handle/310904400/111463


    题名: Casticin impairs cell growth and induces cell apoptosis via cell cycle arrest in human oral cancer SCC-4 cells
    作者: Ch, Guan-Ling;Chou, Guan-Ling;Peng, Shu-Fen;Peng, Shu-Fen;Ching-Lung, Lung L;Liao, Ching-Lung;Heng-Chien, Heng-Chien H;Ho, Heng-Chien;Lu, Kung-Wen;Lu, Kung-Wen;Jin-Cherng, L;Lien, Jin-Cherng;范宗宸;Fan, Chung-Chen;La, Kuang-Chi;Lai, Kuang-Chi;鍾景光*
    贡献者: 生物科技學系
    日期: 2018-02
    上传时间: 2018-10-09 13:24:09 (UTC+8)
    摘要: Casticin, a polymethoxyflavone, present in natural plants, has been shown to have biological activities including anti-cancer activities. Herein, we investigated the anti-oral cancer activity of casticin on SCC-4 cells in vitro. Viable cells, cell cycle distribution, apoptotic cell death, reactive oxygen species (ROS) production, and Ca2+ production, levels of ΔΨm and caspase activity were measured by flow cytometric assay. Cell apoptosis associated protein expressions were examined by Western blotting and confocal laser microscopy. Results indicated that casticin induced cell morphological changes, DNA condensation and damage, decreased the total viable cells, induced G2 /M phase arrest in SCC-4 cells. Casticin promoted ROS and Ca2+ productions, decreases the levels of ΔΨm , promoted caspase-3, -8, and -9 activities in SCC-4 cells. Western blotting assay demonstrated that casticin affect protein level associated with G2/M phase arrest and apoptosis. Confocal laser microscopy also confirmed that casticin increased the translocation of AIF and cytochrome c in SCC-4 cells. In conclusion, casticin decreased cell number through G2 /M phase arrest and the induction of cell apoptosis through caspase- and mitochondria-dependent pathways in SCC-4 cells.
    關聯: ENVIRONMENTAL TOXICOLOGY
    显示于类别:[生物科技學系] 期刊論文

    文件中的档案:

    没有与此文件相关的档案.



    在ASIAIR中所有的数据项都受到原著作权保护.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈