ASIA unversity:Item 310904400/111500
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 90120/105278 (86%)
造访人次 : 8981137      在线人数 : 655
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 查询小技巧:
  • 您可在西文检索词汇前后加上"双引号",以获取较精准的检索结果
  • 若欲以作者姓名搜寻,建议至进阶搜寻限定作者字段,可获得较完整数据
  • 进阶搜寻


    题名: HMGB1 genetic polymorphisms are biomarkers for the development and progression of breast cancer
    作者: Huang, Bi-Fei;Huang, Bi-Fei;Tzen, Huey-En;Tzeng, Huey-En;Chen, Po-Chun;Chen, Po-Chun;Wan, Chao-Qun;Wang, Chao-Qun;Su, Chen-Ming;Su6, Chen-Ming;Wang, Yan;Wang, Yan;Hu, Gui-Nv;Hu, Gui-Nv;Zh, Yong-Ming;Zhao, Yong-Ming;Wang, Qian;Wang, Qian;湯智昕;Chih-Hsin, Tang;*
    贡献者: 生物科技學系
    日期: 2018-03
    上传时间: 2018-10-16 14:50:22 (UTC+8)
    摘要: Breast cancer is a major cause of cancer mortality worldwide. High-mobility group box protein 1 (HMGB1) is a ubiquitous nuclear protein found in all mammal eukaryotic cells that participates in tumor progression, migration and metastasis. HMGB1 overexpression has been indicated in breast cancer patients. However, scant information is available regarding the association between HMGB1 single nucleotide polymorphisms (SNPs) and the risk or prognosis of breast cancer. We report on the association between 4 SNPs of the HMGB1 gene (rs1360485, rs1045411, rs2249825 and rs1412125) and breast cancer susceptibility as well as clinical outcomes in 313 patients with breast cancer and in 217 healthy controls. Patients with one G allele in the rs1360485 or rs2249825 domains are likely to progress to T2 tumor and lymph node metastasis. In addition, the presence of one G allele in SNPs rs1360485 or rs2249825 was associated with a higher risk of progressing to T2 tumor and distant metastasis amongst HER2-enriched and triple-negative breast cancer (TNBC) tumors compared with luminal A and luminal B tumors. Furthermore, having one C allele in the rs1412125 domain increased the risk of pathologic grade 3 disease in HER2-enriched and TNBC tumors. Our results indicate that genetic variations in the HMGB1 gene may serve as an important predictor of breast cancer progression and metastasis.
    關聯: International Journal of Medical Sciences
    显示于类别:[生物科技學系] 期刊論文


    档案 大小格式浏览次数


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈