ASIA unversity:Item 310904400/111537
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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111537


    Title: Add-on Memantine Treatment for Bipolar II Disorder Comorbid with Alcohol Dependence: A 12-Week Follow-Up Study
    Authors: 李聖玉;Lee, Sheng-Yu;王姿云;Wang, Tzu-Yun;陳秀蘭;Chen, Shiou-Lan;張芸瑄;Chang, Yun-Hsuan;黃三原;Huang, San-Yuan;曾念生;Tzeng, Nian-Sheng;王亮人;Wang, Liang-Jen;李怡慧;Lee, I Hui;陳高卿;Chen, Kao ching;楊延光;Yang, Yen Kuang;洪昭雄;Hong, Jau-Shyong;陸汝斌;Lu, Ru-Band
    Contributors: 心理學系
    Keywords: Alcohol Dependence;BDNF;Bipolar II Disorder;Cytokines;Memantine
    Date: 2018-04
    Issue Date: 2018-10-22 11:23:57 (UTC+8)
    Abstract: BACKGROUND:
    Bipolar disorder (BD), especially BD-II, is frequently comorbid with alcohol dependence. Because BD-II and alcohol dependence are neurodegenerative disorders, agents with anti-inflammatory and neurotrophic effects might provide effective therapy. We investigated whether add-on memantine to regular valproic acid treatment ameliorated clinical symptoms, reduced alcohol use, and cytokine levels, and increased plasma brain-derived neurotrophic factor (BDNF) in BD-II patients with comorbid alcohol dependence.

    METHODS:
    In a single-arm 12-week clinical trial, BD-II patients with comorbid alcohol dependence (n = 45) undergoing regular valproic acid treatments were given add-on memantine (5 mg/d). Symptom severity, alcohol use, cytokine (plasma tumor necrosis factor-α and C-reactive protein [CRP], transforming growth factor-β1 [TGF-β1], interleukin-8 [IL-8], IL-10), and plasma BDNF levels were regularly assessed.

    RESULTS:
    Mean within-group decreases in Hamilton Depression Rating Scale (HDRS) and Young Mania Rating Scale (YMRS) scores, alcohol use, CRP, BDNF, and IL-8 levels were significantly different from baseline after 12 weeks of treatment. We found no significant correlation between alcohol use levels and changes in HDRS or YMRS scores. The correlation between reduced alcohol use and reduced TGF-β1 level was significant (B = 0.003, p = 0.019).

    CONCLUSIONS:
    BD-II comorbid with alcohol dependence might benefit from add-on memantine treatment, which significantly reduced clinical severity, alcohol use, and plasma cytokine levels, and increased BDNF levels.
    Relation: ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
    Appears in Collections:[Department of Psychology] Journal Article

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