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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111544


    Title: Impact of matrix metalloproteinase-11 gene polymorphisms upon the development and progression of hepatocellular carcinoma
    Authors: Wang, Bin;Wang, Bin;Hs, Chin-Jung;Hsu, Chin-Jung;Hsiang-Lin, Lin L;Lee, Hsiang-Lin;Chia-Hsuan, Chia-Hsuan C;Chou, Chia-Hsuan;Su, Chen-Ming;Su, Chen-Ming;Yang, Shun-Fa;Yang, Shun-Fa;湯智昕;Chih-Hsin, Tang;*
    Contributors: 生物科技學系
    Keywords: MMP-11 polymorphisms, Hepatocellular carcinoma, Single nucleotide polymorphism, Susceptibility
    Date: 2018-04
    Issue Date: 2018-10-22 11:25:46 (UTC+8)
    Abstract: Hepatocellular carcinoma (HCC) is a liver malignancy and a major cause of cancer mortality worldwide. Matrix metalloproteinase-11 (MMP-11), also known as stromelysin-3, plays a critical role during tumor migration, invasion and metastasis. Here, we report on the association between five single nucleotide polymorphisms (SNPs) - rs738791, rs2267029, rs738792, rs28382575, and rs131451 - of the MMP-11 gene and HCC susceptibility, as well as clinical outcomes, in 293 patients with HCC and in 586 cancer-free controls. We found that carriers of the CT+TT allele of the rs738791 variant were at greater risk of HCC compared with wild-type (CC) carriers. Moreover, carriers of at least one C allele (C/T+C/C genotype) at the MMP-11 SNP rs738792 were likely to progress to Child-Pugh B or C grade, while individuals with at least one C allele (C/T+C/C genotype) at the MMP-11 SNP rs28382575 were at higher risk of developing stage III/IV disease, large tumors or lymph node metastasis. We believe that genetic variations in the MMP-11 gene may help to predict early-stage HCC and act as reliable biomarkers for HCC progression.
    Relation: International Journal of Medical Sciences
    Appears in Collections:[生物科技學系] 期刊論文

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