English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90429/105609 (86%)
Visitors : 10277714      Online Users : 368
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111552


    Title: Association of Matrix Metalloproteinase-7 Genotypes to the Risk of Oral Cancer in Taiwan
    Authors: Liang-Chun, S;Shih, Liang-Chun;Li, Ching-Hao;Li, Ching-Hao;Sun, Kuo-Ting;Sun, Kuo-Ting;Che, Liang-Yu;Chen, Liang-Yu;Hsu, Che-Lun;Hsu, Che-Lun;Hung, Yi-Wen;Hung, Yi-Wen;Wu, Cheng-Nan;Wu, Cheng-Nan;Hsia, Te-Chun;Hsia, Te-Chun;Shen, Te-Chun;Shen, Te-Chun;Cha, Wen-Shin;Chang, Wen-Shin;Sh, Tzu-Ching;Shih, Tzu-Ching;Tsa, Chia-Wen;Tsai, Chia-Wen;包大?;Bau, Da-Tian;*
    Contributors: 生物資訊與醫學工程學系
    Keywords: MMP7;Taiwan;genotype;oral cancer;polymorphism
    Date: 2018-04
    Issue Date: 2018-10-22 11:27:10 (UTC+8)
    Abstract: BACKGROUND/AIM:
    Matrix metalloproteinases (MMPs) play a critical role in inflammation and carcinogenesis, and the expression of mRNA MMP7 in oral squamous cell carcinoma tissues was higher than in the oral lichen planus or normal oral mucosa. However, the genotypic role of MMP7 has never been examined in oral cancer. Therefore, in the current study we aimed to examine the contribution of genotypic variants in the promoter region of MMP7 (A-181G and C-153T) to oral cancer risk in Taiwan.

    MATERIALS AND METHODS:
    In this hospital-based case-control study, 788 patients with oral cancer and 956 gender-and age-matched healthy controls were genotyped for MMP7 A-181G and C-153T via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) methodology.

    RESULTS:
    The distribution pattern of AA, AG and GG for MMP7 promoter A-181G genotype was 88.2, 10.4 and 1.4% in the oral cancer patient group and 89.0, 9.3 and 1.7% in the healthy control group, respectively (p for trend=0.6779), non-significantly differentially distributed between the two groups. There is no polymorphic genotype for MMP7 C-153T among Taiwanese. The comparisons in allelic frequency distribution also support the findings that G allele may not be the risk determinant allele for oral cancer. There is no interaction between the genotypes of MMP7 with age, gender, smoking, alcohol or betel quid consumption on oral cancer risk.

    CONCLUSION:
    Our results indicate that the MMP7 promoter genotypes only play an indirect role in determining the personal susceptibility to oral cancer in Taiwan.
    Relation: ANTICANCER RESEARCH
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

    Files in This Item:

    There are no files associated with this item.



    All items in ASIAIR are protected by copyright, with all rights reserved.


    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback