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|Title: ||The Role of MTHFR Genotype in Colorectal Cancer Susceptibility in Taiwan|
|Authors: ||Lin, Kuei-Man;Lin, Kuei-Man;Yang, Mei-Due;Yang, Mei-Due;Tsa, Chia-Wen;Tsai, Chia-Wen;Cha, Wen-Shin;Chang, Wen-Shin;Hs, Chieh-Lun;Hsiao, Chieh-Lun;Jen, Long-Bin;Jeng, Long-Bin;Yue, Te-Cheng;Yueh, Te-Cheng;Le, Meng-Chih;Lee, Meng-Chih;包大?;Bau, Da-Tian;*|
|Issue Date: ||2018-10-22 11:27:25 (UTC+8)|
To evaluate the contribution of methylenetetrahydrofolate reductase (MTHFR) genotype to the risk of colorectal cancer (CRC) in Taiwan.
MATERIALS AND METHODS:
In this hospital-based case-control study, the role of MTHFR C677T (rs1801133) and A1298C (rs1801131) genotypes in determining CRC risk were investigated among 362 patients with CRC and an equal number of age- and gender-matched healthy individuals.
The percentages of CC, CT and TT genotypes for MTHFR rs1801133 were 64.1%, 29.8% and 6.1% in the CRC group and 51.1%, 37.0% and 11.9% in the control group, respectively (p for trend=0.0006). Analysis of the allelic frequency distribution showed that the variant T allele of MTHFR rs1801133 conferred a lower CRC susceptibility than did the wild-type C allele (odds ratio(OR)=0.66, 95% confidence interval(CI)=0.52-0.84, p=4.32×10-5). For the gene-lifestyle interaction, there were obvious protective effects of MTHFR rs1801133 T allele on the risk of CRC among non-smokers, ever smokers and non-alcohol drinkers, but not drinkers.
MTHFR rs1801133 T allele serves as a predictive marker for CRC risk and future studies with larger samples and functional evaluation are warranted to validate the current findings.
|Relation: ||ANTICANCER RESEARCH|
|Appears in Collections:||[生物資訊與醫學工程學系 ] 期刊論文|
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