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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111563


    Title: The Contribution of MMP-7 Genotypes to Colorectal Cancer Susceptibility in Taiwan
    Authors: Yue, Te-Cheng;Yueh, Te-Cheng;Wu, Cheng-Nan;Wu, Cheng-Nan;Hung, Yi-Wen;Hung, Yi-Wen;Cha, Wen-Shin;Chang, Wen-Shin;Fu, Chun-Kai;Fu, Chun-Kai;Pe, Jen-Sheng;Pei, Jen-Sheng;Ming-Hsien, W;Wu, Ming-Hsien;Lai, Yi-Liang;Lai, Yi-Liang;Lee, Yi-Min;Lee, Yi-Min;Shiou-Ting, Y;Yen, Shiou-Ting;Li, Hsin-Ting;Li, Hsin-Ting;Tsa, Chia-Wen;Tsai, Chia-Wen;包大?;Bau, Da-Tian;*
    Contributors: 生物資訊與醫學工程學系
    Keywords: Colorectal cancer, genotype, MMP-7, polymorphism, Taiwan
    Date: 2018-05
    Issue Date: 2018-10-22 11:28:19 (UTC+8)
    Abstract: Background/Aim: Matrix metalloproteinases (MMPs) play important roles in inflammation and carcinogenesis, but the genotypic role of MMP-7 has never been investigated in colorectal cancer (CRC) among the Taiwanese. Therefore, in this study we aimed to evaluate the contribution of MMP-7 genotypes to the risk of CRC in Taiwan. Materials and Methods: In this case-control study, MMP-7 A-181G and C-153T promoter genotypes were determined and their association with CRC risk were investigated among 362 CRC patients and 362 age- and gender-matched healthy controls. In addition, the interaction of MMP-7 genotypes and personal behaviors were also examined. Results: The percentages of variant AG and GG for MMP-7 A-181G genotypes were 10.5% and 1.7% in the CRC group and 11.9% and 2.2% in the control group, respectively (p for trend=0.7145). The allelic frequency distribution analysis showed that the variant G allele of MMP-7 A-181G conferred a slight but non-significant decreased CRC susceptibility to the wild-type C allele (odds ratio (OR)=0.86, 95% confidence interval (CI)=0.64-1.31, p=0.37). Taiwanese all harbour the CC genotype at MMP-7 C-153T. As for the gene–lifestyle interaction, there were no obvious joint effects of MMP-7 A-181G genotype on the risk of CRC among ever smoker, alcohol drinker, non-smoker or non-drinker subgroups. No statistically significant correlation was observed between MMP-7 A-181G genotypic distributions and age, gender, tumor size, location or metastasis status. Conclusion: The genotypes of MMP-7 A-181G may play an indirect role in determining personal susceptibility to CRC and prognosis. The further genotyping work on MMP-7 and other genes (such as other MMPs, oncogenes and tumor suppression genes) on CRC susceptibility and prognosis, should be taken into consideration spontaneously in the precision medicine era.
    Relation: Cancer Genomics & Proteomics
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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