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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111578


    Title: High Levels of Circulating Endothelial Progenitor Cells in Patients with Diabetic Retinopathy are Positively Associated with ARHGAP22 Expression
    Authors: 黃毓銓;廖文伶;林正明;陳清助;劉詩平;Liu, Shih-Ping;陳世殷;Lin, Yu-Ning;Lin, Yu-Ning;Lei, Yu-Jie;Lei, Yu-Jie;劉奐亭;陳裕仁;蔡輔仁*
    Contributors: 社會工作學系
    Date: 2018-04
    Issue Date: 2018-10-22 11:34:11 (UTC+8)
    Abstract: Diabetic retinopathy (DR) is a common microvascular complication of diabetes. Circulating endothelial progenitor cells (EPCs) are derived from bone marrow and are characterized by pathological retinal neovascularization. Rho GTPase Activating Protein 22 (ARHGAP22) is a DR susceptibility gene that interacts with its downstream regulatory protein ras-related C3 botulinum toxin substrate 1 (Rac1), to assist in endothelial cell angiogenesis and increasing capillary permeability. The aim of this study was to elucidate the relationship between ARHGAP22 expression and EPC levels in type 2 diabetes (T2D) patients with DR. Fifty T2D patients with DR were recruited. Circulating EPCs were characterized as CD31+/vascular endothelial growth factor-2+/CD45dim/CD133+ and were quantified using triple staining flow cytometry. Real-time polymerase chain reaction tests were used to quantify ARHGAP22 expression. We found that T2D patients with proliferative DR had significantly lower EPC levels than those with non-proliferative DR (P = 0.028). T2D patients with EPC levels above the median value (> 4 cells/105 events) had higher levels of ARHGAP22 expression (P = 0.002). EPC levels were positively correlated with ARHGAP22 expression (r = 0.364, P = 0.009). Among T2D patients with DR, a higher expression of ARHGAP22 was associated with higher levels of EPCs. ARHGAP22 may be involved in the mobilization or active circulation of EPCs, thus contributing to neovascularization during DR development.
    Relation: Oncotarget
    Appears in Collections:[社會工作學系] 期刊論文

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