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|Title: ||Three-year renal function trajectory and its association with adverse renal event in patients with type 2 diabetes|
|Authors: ||李采娟;Yu, Tzu-Yun;Yu, Tzu-Yun;Li, Chia-Ing;Li, Chia-Ing;Chiu-Shong, L;Liu, Chiu-Shong;Lin, Wen-Yuan;Lin, Wen-Yuan;Chih-Hsueh, L;Lin, Chih-Hsueh;Yang, Sing-Yu;Yang, Sing-Yu;林正介|
|Issue Date: ||2018-10-22 11:41:14 (UTC+8)|
The study evaluated associations between 3-year eGFR trajectory patterns and adverse renal event in diabetic patients.
Adverse renal event was defined as sustained eGFR <60 or one ACR >300 mg/g creatinine. Cox proportional hazards models evaluated association between eGFR trajectory patterns and adverse renal event.
We detected six clusters. Cluster 1 had a stable but relatively low baseline eGFR level (n = 823, 20.52%), cluster 2 had a high baseline eGFR level, but slightly decreased afterwards (n = 1708, 42.59%), cluster 3 had an increasing eGFR during the first 15-month follow-up and then a decline rate (n = 505, 12.59%), cluster 4 decreased during the first 9-month follow-up and then remained stable (n = 774, 19.30%), cluster 5 had a sharp decline and then was elevated after 21 months until the end of follow-up (n = 135, 3.37%), and cluster 6 had an extremely fluctuating eGFR and then a sharp increase at the last 12-month period (n = 65, 1.62%). Clusters 1, 3, and 4 show increased adverse renal risks compared with cluster 2 (2.24, 1.69–2.97; 2.70, 2.02–3.61; and 2.15, 1.64–2.83, respectively).
Patients with sustained low-level renal function, renal decline, or increasing trend in eGFR trajectory encountered an increased CKD risk.
|Relation: ||JOURNAL OF DIABETES AND ITS COMPLICATIONS|
|Appears in Collections:||[健康產業管理學系] 期刊論文|
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