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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111621


    Title: Osteogenic and angiogenic potentials of the cell-laden hydrogel/mussel-inspired calcium silicate complex hierarchical porous scaffold fabricated by 3D bioprinting
    Authors: 陳怡文;Chen, Yi-Wen;沈育芳;Shen, Yu-Fang;Ho, Chia-Che;Ho, Chia-Che;Yu, Joyce;Yu, Joyce;And, Yuan-Haw;Wu, Yuan-Haw Andrew;Wang, Kan;Wang, Kan;Cheng-Ting, S;Shih, Cheng-Ting;謝明佑;Shie, Ming-You
    Contributors: 生物資訊與醫學工程學系
    Date: 2018-10
    Issue Date: 2018-12-24 16:07:59 (UTC+8)
    Abstract: 3D printing has been popularly used in the bone tissue engineering, as many of the biomaterials for this field of study can be prepared for and produced from this additive manufacturing technique. In this study, we strategized a solvent-free processing to fabricate the polydopamine-modified calcium silicate (PDACS)/poly-caprolactone (PCL) scaffold with Wharton's jelly mesenchymal stem cells (WJMSCs) incorporated with human umbilical vein endothelial cells (HUVEC)-laden hydrogel. The PDACS/PCL/hydrogel 3D scaffold yielded a Young's modulus of the 3D scaffolds as high as 75 MPa. In addition, the vascular morphogenesis and cellular behaviors regulated by our hybrid scaffolds were also intricately evaluated. Furthermore, the HUVEC in the bioink exhibited higher levels of angiogenic biomarkers and showed potential for the formation of complex vascular networks. Higher levels of bone formation proteins were also observed in our composites. Such a hybrid of synthetic materials with cell constituents not only enhances osteogenesis but also stimulates vessel network development in angiogenesis, presenting the fact that 3D printing can be further applied in improving bone tissue regeneration in numerous aspects. We believe that this method may serve as a useful and effective approach for the regeneration of defective complex hard tissues in deep bone structures.
    Relation: Materials Science and Engineering C
    Appears in Collections:[生物資訊與醫學工程學系 ] 期刊論文

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