ASIA unversity:Item 310904400/111626
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 90453/105671 (86%)
Visitors : 16036550      Online Users : 130
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item:

    Title: Interleukin-18 promoter genotype is associated with the risk of nasopharyngeal carcinoma in Taiwan
    Authors: Hua, Chung-Yu;Huang, Chung-Yu;Cha, Wen-Shin;Chang, Wen-Shin;Tsa, Chia-Wen;Tsai, Chia-Wen;Hsia, Te-Chun;Hsia, Te-Chun;Shen, Te-Chun;Shen, Te-Chun;Bau, Da-Tian;Bau, Da-Tian;Shui, Hao-Ai;Shui, Hao-Ai
    Contributors: 生物資訊與醫學工程學系
    Date: 2018-10
    Issue Date: 2018-12-24 16:08:21 (UTC+8)
    Abstract: Background
    The incidence rate of nasopharyngeal carcinoma (NPC) has been documented to be high in Southeast Asia. Interleukin-18 (IL-18) is a multifunctional cytokine that augments interferon-γ production and acts as an important immunomediator in the development of several types of cancer.

    Patients and methods
    This case–control study evaluated the role of IL-18 in NPC at the DNA level by genotyping its promoter polymorphisms at positions -656, -607, and -137 in a Taiwanese population. A total of 176 patients with NPC and age- and gender-matched 352 noncancer controls were included in this study.

    The CC genotype of the IL-18-607 polymorphism was found to be associated with significantly decreased risks of NPC compared to the AA genotype (crude OR =0.50, 95% CI =0.29–0.84, P=0.0093). This significant difference persisted even in the dominant and recessive models. A significantly lower C allele frequency at position -607 was detected in the NPC group

    (41.8% vs 50.3%; OR =0.77; 95% CI =0.63–1.04, P=0.0089). Regarding IL-18-656 and -137 polymorphisms, there were no differential distributions of their genotypes between the NPC and control groups. After substratification of the subjects according to their smoking, alcohol consumption, and areca chewing status, the genotype distribution of the IL-18-607 polymorphism was found to be different only among nonsmokers between the NPC and control subgroups.

    This study suggests that IL-18 plays an important role in the carcinogenesis of NPC in Taiwan and that the genotype–phenotype correlation of IL-18-607 polymorphism and its contribution to NPC need to be investigated further.
    Relation: Cancer Management and Research
    Appears in Collections:[Department of Biomedical informatics  ] Journal Article

    Files in This Item:

    File SizeFormat

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback