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    ASIA unversity > 醫學暨健康學院 > 視光學系 > 期刊論文 >  Item 310904400/111664


    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111664


    Title: Bisphenol A exhibits cytotoxic or genotoxic potential via oxidative stressassociated mitochondrial apoptotic pathway in murine macrophages
    Authors: Huang, Fu-Mei;Huanga, Fu-Mei;Chan, Yu-Chao;Chang, Yu-Chao;Shiuan-Shinn;Lee, Shiuan-Shinn;Yung-Chyuan;Ho, Yung-Chyuan;Ya, Ming-Ling;Yang, Ming-Ling;林惠雯;Lin, Hui-Wen;Ku, Yu-Hsiang;Kuan, Yu-Hsiang
    Contributors: 視光學系
    Date: 2018-10
    Issue Date: 2018-12-24 17:20:45 (UTC+8)
    Abstract: Bisphenol A (BPA) is primarily used in production of polycarbonate plastics and epoxy resins including plastic containers. BPA is an endocrine disruptor and supposes to induce asthma and cancer. However, so far only a few evidences have shown the BPA-induced toxic effect and its related mechanism in macrophages. BPA demonstrated cytotoxic effect on RAW264.7 macrophages in a concentration and time-dependent manner. BPA induces necrosis, apoptosis, and genotoxicity in a concentration-dependent manner. Phosphorylation of cytochrome C (cyto C) and p53 was due to mitochondrial disruption via BCL2 and BCL-XL downregulation and BAX, BID, and BAD upregulation. Both caspase-dependent, including caspase-9, caspase-3, and PARP-1 cleavage, and caspase-independent, such as nuclear translocation of AIF, pathways were activated by BPA. Furthermore, generation of reactive oxygen species (ROS) and reduction of antioxidative enzyme activities were induced by BPA. Parallel trends were observed in the effect of BPA on cytotoxicity, apoptosis, genotoxicity, p53 phosphorylation, BCL2 family expression exchange, caspase-dependent and independent apoptotic pathways, and ROS generation in RAW264.7 macrophages. Finally, BPA-exhibited cytotoxicity, apoptosis, and genotoxicity could be inhibited by N-acetylcysteine. These results indicated that the toxic effect of BPA was functioning via oxidative stress-associated mitochondrial apoptotic pathway in macrophages.
    Relation: FOOD AND CHEMICAL TOXICOLOGY
    Appears in Collections:[視光學系] 期刊論文

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