English  |  正體中文  |  简体中文  |  Items with full text/Total items : 93288/109022 (86%)
Visitors : 21041584      Online Users : 181
RC Version 6.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Tips:
  • please add "double quotation mark" for query phrases to get precise results
  • please goto advance search for comprehansive author search
  • Adv. Search
    HomeLoginUploadHelpAboutAdminister Goto mobile version

    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111907

    Title: C-terminus of Hsc70-interacting protein (CHIP) enhances stemness properties of human Whartons jelly mesenchymal stem cell
    Authors: 楊靖國;馮致中;羅正汎;陳俊瑋;Padma, V. V;Padma, V. V;賴昭宏;陳冬生;陳瑞杰;廖柏翔;黃志揚;Huang;Chih-Yang
    Contributors: 生物科技學系
    Date: 2018-11
    Issue Date: 2019-09-02 14:33:49 (UTC+8)
    Abstract: Mesenchymal stem cells are an attractive source of multipotent cells in part because they are easy to obtain. Several E3 ligases regulate the stability and functions of various factors in different adult stem cells through the ubiquitylation pathway. We investigated the C-terminus of Hsc70-interacting protein (CHIP) E3 ligase that regulates pluripotency of human Wharton's jelly mesenchymal stem cells (hWJMSC). We found that CHIP increases protein kinase B (Akt) phosphorylation by decreased expression of phosphatase and tensin homolog (PTEN), which suggests improvement of the survival pathway by CHIP over-expression. We also found that increased CHIP expression induced Sox2 and NANOG, which can promote stem cell self-renewal and prevent oxidative stress-induced senescence of hWJMSC by decreased p21. We found that CHIP could be used to enhance the multiple functions of hWJMSC.

    Hsc70-interacting protein; Wharton’s jelly; human; mesenchymal stem cell; phosphatase and tensin homolog (PTEN); protein kinase B (Akt); self-renewal
    Appears in Collections:[生物科技學系] 期刊論文

    Files in This Item:

    There are no files associated with this item.

    All items in ASIAIR are protected by copyright, with all rights reserved.

    DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback