ASIA unversity:Item 310904400/111907
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    题名: C-terminus of Hsc70-interacting protein (CHIP) enhances stemness properties of human Whartons jelly mesenchymal stem cell
    作者: 楊靖國;馮致中;羅正汎;陳俊瑋;Padma, V. V;Padma, V. V;賴昭宏;陳冬生;陳瑞杰;廖柏翔;黃志揚;Huang;Chih-Yang
    贡献者: 生物科技學系
    日期: 2018-11
    上传时间: 2019-09-02 14:33:49 (UTC+8)
    摘要: Mesenchymal stem cells are an attractive source of multipotent cells in part because they are easy to obtain. Several E3 ligases regulate the stability and functions of various factors in different adult stem cells through the ubiquitylation pathway. We investigated the C-terminus of Hsc70-interacting protein (CHIP) E3 ligase that regulates pluripotency of human Wharton's jelly mesenchymal stem cells (hWJMSC). We found that CHIP increases protein kinase B (Akt) phosphorylation by decreased expression of phosphatase and tensin homolog (PTEN), which suggests improvement of the survival pathway by CHIP over-expression. We also found that increased CHIP expression induced Sox2 and NANOG, which can promote stem cell self-renewal and prevent oxidative stress-induced senescence of hWJMSC by decreased p21. We found that CHIP could be used to enhance the multiple functions of hWJMSC.

    KEYWORDS:
    Hsc70-interacting protein; Wharton’s jelly; human; mesenchymal stem cell; phosphatase and tensin homolog (PTEN); protein kinase B (Akt); self-renewal
    關聯: BIOTECHNIC & HISTOCHEMISTRY
    显示于类别:[生物科技學系] 期刊論文

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