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| Title: | Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyob last and in spontaneo usly hypertensive rats |
| Authors: | Chi, Jui-Ting
Chiang, Jui-Ting
Farheen, Khan
Badrealam, Khan Farheen
Marthandam, A
Shibu, Marthandam Asokan
Kuo, Chia-Hua
Kuo, Chia-Hua
Hu, Chih-Yang
Huang, Chih-Yang
Ch, Bih-Cheng
Chen, Bih-Cheng
Lin, Yueh-Min
Lin, Yueh-Min
Padma, Vijaya
Viswanadha, Vijaya Padma
Kuo, Wei-Wen
Kuo, Wei-Wen
黃志揚
Huang
Chih-Yang |
| Contributors: | 生物科技學系 |
| Date: | 2018-11 |
| Issue Date: | 2019-09-02 14:35:17 (UTC+8) |
| Abstract: | Eriobotrya japonica (EJ) is a traditional Chinese plant with high medicinal value. EJ extracts are reported to exhibit antioxidant and anti-inflammatory biological attributes. The current study aims to evaluate the prospective efficacy of E. japonica leave extract (EJLE) against Angiotensin-II induced cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats (SHRs). For the in vitro studies, Angiotensin-II pretreated H9c2 cells were treated with EJLE and analyzed through Western blotting and rhodamine phalloidin staining for their cardio-protective attributes. In the in vivo studies, 12-week-old SHRs were randomly divided into groups: SHRs supplemented with EJLE, control SHR group supplemented with PBS; in addition, a control group of Wistar-Kyoto rats (WKY) was also employed. All rats were supplemented twice a week for 8 week time interval. Finally, echocardiography, morphological, histology, and Western blot analysis were performed to assess their role against cardiac hypertrophy. Interestingly, we could observe that supplementation of EJLE could rescue Ang-II induced cardiac hypertrophy as evident through Western blot, rhodamine phalloidin staining, and Hematoxylin-Eosin staining. Notably, morphological and echocardiography data provided further supports for their ability to ameliorate cardiac characteristics. Cumulatively, the results clearly suggests that supplementation of EJLE promotes cardio-protective effects through amelioration of cardiac hypertrophy in vitro and in vivo. |
| Relation: | ENVIRONMENTAL TOXICOLOGY |
| Appears in Collections: | [生物科技學系] 期刊論文
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