Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyob last and in spontaneo usly hypertensive rats

ASIA unversity > 醫學暨健康學院 > 生物科技學系 > 期刊論文 > Item 310904400/111908

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题名:	Eriobotrya japonica ameliorates cardiac hypertrophy in H9c2 cardiomyob last and in spontaneo usly hypertensive rats
作者:	Chi, Jui-Ting Chiang, Jui-Ting Farheen, Khan Badrealam, Khan Farheen Marthandam, A Shibu, Marthandam Asokan Kuo, Chia-Hua Kuo, Chia-Hua Hu, Chih-Yang Huang, Chih-Yang Ch, Bih-Cheng Chen, Bih-Cheng Lin, Yueh-Min Lin, Yueh-Min Padma, Vijaya Viswanadha, Vijaya Padma Kuo, Wei-Wen Kuo, Wei-Wen 黃志揚 Huang Chih-Yang
贡献者:	生物科技學系
日期:	2018-11
上传时间:	2019-09-02 14:35:17 (UTC+8)
摘要:	Eriobotrya japonica (EJ) is a traditional Chinese plant with high medicinal value. EJ extracts are reported to exhibit antioxidant and anti-inflammatory biological attributes. The current study aims to evaluate the prospective efficacy of E. japonica leave extract (EJLE) against Angiotensin-II induced cardiac hypertrophy in H9c2 cardiomyoblast and in spontaneously hypertensive rats (SHRs). For the in vitro studies, Angiotensin-II pretreated H9c2 cells were treated with EJLE and analyzed through Western blotting and rhodamine phalloidin staining for their cardio-protective attributes. In the in vivo studies, 12-week-old SHRs were randomly divided into groups: SHRs supplemented with EJLE, control SHR group supplemented with PBS; in addition, a control group of Wistar-Kyoto rats (WKY) was also employed. All rats were supplemented twice a week for 8 week time interval. Finally, echocardiography, morphological, histology, and Western blot analysis were performed to assess their role against cardiac hypertrophy. Interestingly, we could observe that supplementation of EJLE could rescue Ang-II induced cardiac hypertrophy as evident through Western blot, rhodamine phalloidin staining, and Hematoxylin-Eosin staining. Notably, morphological and echocardiography data provided further supports for their ability to ameliorate cardiac characteristics. Cumulatively, the results clearly suggests that supplementation of EJLE promotes cardio-protective effects through amelioration of cardiac hypertrophy in vitro and in vivo.
關聯:	ENVIRONMENTAL TOXICOLOGY
显示于类别:	[生物科技學系] 期刊論文

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