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    Please use this identifier to cite or link to this item: http://asiair.asia.edu.tw/ir/handle/310904400/111909


    Title: Neferine suppresses diethylnitrosamine-induced lung carcinogenesis in Wistar rats
    Authors: Kalaiselvi, S;Sivalingam, Kalaiselvi;Amirt, Vinoth;Amirthalingam, Vinoth;Karunagaran;Ganasan, Karunagaran;黃志揚;Huang;Chih-Yang;Padma, Vijaya;Viswanadha, Vijaya Padma
    Contributors: 生物科技學系
    Date: 2018-11
    Issue Date: 2019-09-02 14:36:48 (UTC+8)
    Abstract: Neferine is a bisbenzylisoquinoline alkaloid isolated from the embryos of lotus which has attracted attention for its anti-inflammatory and anti-cancer activities. The aim of this study was to evaluate the anti-cancer effect of neferine against diethylnitrosamine (DEN)-induced lung carcinogenesis in Wistar rats and to explore the underlying molecular mechanism. DEN-induced oxidative stress is mediated by alterations in the levels of pulmonary reactive-oxygen species, lipid peroxidation, protein carbonyl content and antioxidant status. Thus, treatment with neferine restored cellular normalcy, highlighting the antioxidant potential of neferine in mitigating the oxidative stress-mediated damage produced during DEN-induced lung carcinogenesis. Histopathological analysis showed disorganized alveolar structure, thickened alveolar wall, infiltration of inflammatory cells in DEN-induced rats, the damage was significantly reduced upon neferine treatment. DEN-induced rats exhibited increased gene expression of NF-κB, COX-2, CYP2E1, VEGF, Bcl-2, PI3K/AKT/mTOR and significantly decreased the gene expression of p53, Bax, caspase-9 and caspase-3. Neferine treatment restored the DEN- induced alteration of these gene expression levels. Further, blotting analysis also revealed increased expression of NF-κB, COX-2, Bcl-2 and decreased expression of Bax, caspase-9 and caspase-3 proteins in DEN-induced rats. Neferine treatment restored the expression of these proteins in DEN- induced lung carcinogenesis.
    Relation: FOOD AND CHEMICAL TOXICOLOGY
    Appears in Collections:[生物科技學系] 期刊論文

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